The use of N-acetylcysteine for the prevention of hypertension in the reduced uterine perfusion pressure model for preeclampsia in Sprague-Dawley rats
| Autor: | Avtar K. Singh, Manjeet K. Paintlia, Eugene Y. Chang, Inderjit Singh, Ernest Barbosa |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
Mean arterial pressure
medicine.medical_specialty medicine.medical_treatment Uterus Blood Pressure Preeclampsia Rats Sprague-Dawley Acetylcysteine Pre-Eclampsia Pregnancy Internal medicine medicine Animals Saline business.industry Obstetrics and Gynecology medicine.disease Rats Disease Models Animal Blood pressure Endocrinology medicine.anatomical_structure Fetal Weight In utero Hypertension Female business Perfusion medicine.drug |
| Zdroj: | American Journal of Obstetrics and Gynecology. 193:952-956 |
| ISSN: | 0002-9378 |
| Popis: | Objective To determine whether N-acetylcysteine attenuates abnormal changes in the reduced uterine perfusion pressure model. Study design Twenty-four timed-pregnant Sprague-Dawley rats underwent sham surgery or the reduced uterine perfusion pressure procedure on day 15 of 22. Reduced uterine perfusion pressure animals were treated with N-acetylcysteine (100 mg/kg) or saline twice daily until delivery. On day 21 of 22, mean arterial pressure was determined and maternal tissue was collected and stored. Pups and pup brains were weighed. Statistical analysis was performed using 1-way analysis of variance and the Tukey-Kramer test with significance at P Results There was a significant increase in blood pressure with the reduced uterine perfusion pressure procedure ( P =.016), which was alleviated by N-acetylcysteine ( P =.044). There was a significant decrease in pup weight and brain weight with the reduced uterine perfusion pressure procedure ( P =.043 and P =.046, respectively). N-acetylcysteine restored pup brain weight ( P =.021) but had no significant effect on pup weight. Conclusion N-acetylcysteine reduced blood pressure without adversely effecting fetal weight. |
| Databáze: | OpenAIRE |
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