Prevalence of osteoporosis and osteopenia diagnosed using quantitative CT in 296 consecutive lumbar fusion patients
| Autor: | Alexander P. Hughes, Courtney Ortiz Miller, Frank P. Cammisa, Marie-Jacqueline Reisener, Brandon B. Carlson, Jingyan Yang, Toshiyuki Shirahata, Andrew A. Sama, Federico P. Girardi, Stephan N. Salzmann, John A. Carrino |
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| Rok vydání: | 2020 |
| Předmět: |
musculoskeletal diseases
Adult Male medicine.medical_specialty Osteoporosis Prevalence Asymptomatic 030218 nuclear medicine & medical imaging Metabolic bone disease Cohort Studies 03 medical and health sciences Young Adult 0302 clinical medicine Lumbar Bone Density Internal medicine medicine Humans Prospective Studies Quantitative computed tomography Aged Retrospective Studies Bone mineral Aged 80 and over Lumbar Vertebrae medicine.diagnostic_test business.industry General Medicine Middle Aged medicine.disease Osteopenia Bone Diseases Metabolic Spinal Fusion Surgery Female Neurology (clinical) medicine.symptom business Tomography X-Ray Computed 030217 neurology & neurosurgery |
| Zdroj: | Neurosurgical focus. 49(2) |
| ISSN: | 1092-0684 |
| Popis: | OBJECTIVEOsteoporosis is a metabolic bone disease that increases the risk for fragility fractures. Screening and diagnosis can be achieved by measuring bone mineral density (BMD) using quantitative CT tomography (QCT) in the lumbar spine. QCT-derived BMD measurements can be used to diagnose osteopenia or osteoporosis based on American College of Radiology (ACR) thresholds. Many reports exist regarding the disease prevalence in asymptomatic and disease-specific populations; however, osteoporosis/osteopenia prevalence rates in lumbar spine fusion patients without fracture have not been reported. The purpose of this study was to define osteoporosis and osteopenia prevalence in lumbar fusion patients using QCT.METHODSA retrospective review of prospective data was performed. All patients undergoing lumbar fusion surgery who had preoperative fine-cut CT scans were eligible. QCT-derived BMD measurements were performed at L1 and L2. The L1–2 average BMD was used to classify patients as having normal findings, osteopenia, or osteoporosis based on ACR criteria. Disease prevalence was calculated. Subgroup analyses based on age, sex, ethnicity, and history of abnormal BMD were performed. Differences between categorical groups were calculated with Fisher’s exact test.RESULTSOverall, 296 consecutive patients (55.4% female) were studied. The mean age was 63 years (range 21–89 years). There were 248 (83.8%) patients with ages ≥ 50 years. No previous clinical history of abnormal BMD was seen in 212 (71.6%) patients. Osteopenia was present in 129 (43.6%) patients and osteoporosis in 44 (14.9%). There were no prevalence differences between sex or race. Patients ≥ 50 years of age had a significantly higher frequency of osteopenia/osteoporosis than those who were < 50 years of age.CONCLUSIONSIn 296 consecutive patients undergoing lumbar fusion surgery, the prevalence of osteoporosis was 14.9% and that for osteopenia was 43.6% diagnosed by QCT. This is the first report of osteoporosis disease prevalence in lumbar fusion patients without vertebral fragility fractures diagnosed by QCT. |
| Databáze: | OpenAIRE |
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