Analysis of allelic expression patterns of IL-2, IL-3, IL-4, and IL-13 in human CD4+ T cell clones
| Autor: | Eric L. Kaijzel, Tineke van der Pouw-Kraan, Cornelis L. Verweij, A Bakker, Tom W J Huizinga, Jean-Pierre Bayley, Eddy A. Wierenga |
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| Přispěvatelé: | Cell Biology and Histology, VU University medical center |
| Rok vydání: | 2003 |
| Předmět: |
CD4-Positive T-Lymphocytes
Heterozygote Genotype medicine.medical_treatment T cell Immunology Gene Expression Biology Polymorphism Single Nucleotide Mice medicine Animals Humans Immunology and Allergy Allele Gene Alleles Interleukin 4 Genetics Interleukin-13 Polymorphism Genetic Base Sequence Cd4 t cell Interleukins Molecular biology Clone Cells Cytokine medicine.anatomical_structure Interleukin 13 Interleukin-2 Interleukin-3 Human genome Interleukin-4 |
| Zdroj: | European journal of immunology, 33(8), 2142-2148. Wiley-VCH Verlag Bayley, J P, Bakker, AM, Kaijzel, EL, Wierenga, EA, van der Pouw Kraan, C T M, Huizinga, T W & Verweij, C L 2003, ' Analysis of allelic expression patterns of IL-2, IL-3, IL-4, and IL-13 in human CD4+ T cell clones. ', European Journal of Immunology, vol. 33, no. 8, pp. 2142-8 . https://doi.org/10.1002/eji.200323976 European Journal of Immunology, 33(8), 2142-8. Wiley-VCH Verlag |
| ISSN: | 1521-4141 0014-2980 |
| DOI: | 10.1002/eji.200323976 |
| Popis: | The occurrence of monoallelic expression of cytokine genes in single cells has been convincingly demonstrated, but there have been few reports of this phenomenon in T cell clones. Here we describe studies on the expression of alleles of the human genes encoding IL-2, IL-3, IL-4, and IL-13 in human CD4(+) T cell clones. In contrast to the results reported in mouse T cell clones and single human T cells, we found no evidence for the monoallelic expression of the IL-2, IL-3, and IL-13 genes. The gene for IL-4 showed an imbalance in expression from each allele, indicating differential expression of IL-4 alleles within or between IL-4-expressing cells. |
| Databáze: | OpenAIRE |
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