Regional Differences in Hypertensive Cardiovascular Remodeling Between Fishing and Farming Communities in Japan
| Autor: | Yuichiro Yano, Takashi Inokuchi, Naoto Yokota, Kazuyuki Shimada, Noboru Tamaki, Masahiko Nagata, Satoshi Hoshide, Shuntaro Matsuda, Yoshimasa Kanemaru, Toshiaki Hidaka, Kazuomi Kario, Masachika Kuwabara |
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| Rok vydání: | 2011 |
| Předmět: |
Male
medicine.medical_specialty Docosahexaenoic Acids Heart Ventricles Fisheries Arginine chemistry.chemical_compound Japan Internal medicine Fatty Acids Omega-3 Internal Medicine medicine Humans Aged Ultrasonography Geographic difference chemistry.chemical_classification business.industry Agriculture Middle Aged Eicosapentaenoic acid Fishery Carotid Arteries Cross-Sectional Studies Blood pressure Eicosapentaenoic Acid Intima-media thickness chemistry Docosahexaenoic acid Hypertension cardiovascular system Cardiology Female Asymmetric dimethylarginine business Body mass index Polyunsaturated fatty acid |
| Zdroj: | American Journal of Hypertension. 24:437-443 |
| ISSN: | 1941-7225 0895-7061 |
| Popis: | BACKGROUND Effects of dietary n-3 polyunsaturated fatty acids (n-3 PUFA) intake on the cardiovascular system have been reported, and thus we hypothesized that the prevalence of hypertensive cardiovascular remodeling would be lower in a fishing than a farming community. METHODS We recruited 263 essential hypertensives from a fishing and 333 from a farming village; all subjects were ≥40 years (mean 73 years; 42% men). They were cross-sectionally examined for serum eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), asymmetric dimethylarginine (ADMA) levels, left ventricular mass index (LVMI), and common-carotid artery (CCA) and internal-carotid artery (ICA) intima-media thickness (IMT). RESULTS Compared to the patients in the farming village, those in the fishing village had higher serum EPA and DHA levels (63.3 vs.70.9 µg/ml, 137.2 vs.157.8 µg/ml) and lower ADMA levels (0.49 vs.0.47 nmol/ml; all P < 0.05). LVMI and both CCA-IMT and ICA-IMT levels were lower in the fishing than the farming village (113.2 vs.121.6 g/m(2), 0.88 vs.0.94 mm, 1.10 vs.1.17 mm: all P < 0.01) even after adjustment for age, sex, body mass index (BMI), duration of hypertensive medication, number of antihypertensive medications, and 24-h systolic blood pressure (SBP) level. The differences in LVMI and IMT levels between these communities also remained unchanged (all P < 0.01) after additional adjustment for the regional differences in EPA, DHA, and ADMA levels. A multivariable linear regression analysis showed that the difference in place of residence was independently associated with LVMI as well as with both CCA-IMT and ICA-IMT levels (all P < 0.01). CONCLUSION The prevalence of cardiovascular remodeling was significantly lower in patients in the fishing community than in those in the farming community. Further investigations are required to explain the mechanisms underlying this association. |
| Databáze: | OpenAIRE |
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