Long-term outcomes of community-acquired versus hospital-acquired acute kidney injury: a retrospective analysis

Autor: Der Mesropian Pj, Roy O. Mathew, Eisele G, Kalamaras Js, Asif A, Kenneth R. Phelps
Rok vydání: 2014
Předmět:
medicine.medical_specialty
Time Factors
Hospitals
Veterans
New York
Renal function
Kaplan-Meier Estimate
Kidney
urologic and male genital diseases
Severity of Illness Index
chemistry.chemical_compound
Risk Factors
Internal medicine
Prevalence
medicine
Humans
Rifle
Cumulative incidence
Veterans Affairs
Proportional Hazards Models
Retrospective Studies
Creatinine
Chi-Square Distribution
urogenital system
business.industry
Incidence
Acute kidney injury
Retrospective cohort study
Recovery of Function
General Medicine
Acute Kidney Injury
medicine.disease
female genital diseases and pregnancy complications
Surgery
Hospitalization
Logistic Models
Treatment Outcome
chemistry
Nephrology
Multivariate Analysis
Disease Progression
Kidney Failure
Chronic
business
Biomarkers
Glomerular Filtration Rate
Kidney disease
Zdroj: Clinical Nephrology. 81:174-184
ISSN: 0301-0430
DOI: 10.5414/cn108153
Popis: To compare long-term outcomes in CA-AKI to HA-AKI. The hypothesis was that renal and patient survival would be better in CA-AKI than in HA-AKI.Retrospective cohort analysis of patients hospitalized from 2004 to 2005, in Upstate New York Veterans Affairs hospitals. The groups: CA-AKI (n = 560), HA-AKI (n = 158), or No AKI (NA) (n = 2,320). Risk, injury, failure, loss, and end-stage kidney (RIFLE) criterion was used to define AKI.doubling of serum creatinine, endstage renal disease (ESRD), death, and a composite of the three.de novo chronic kidney disease (CKD), recovery of renal function, and re-admission rate. The cumulative incidence of outcomes was determined over a period of 3 years after discharge.CA-AKI was 3.5 times as prevalent as HA-AKI. In comparison to patients with HA-AKI, those with CA-AKI had better estimated glomerular filtration rate (71.3 vs. 61.1 mL/min/1.73 m(2), p0.001) and lower prevalence of CKD (42.3 vs. 51.9%, p = 0.03) at baseline. More patients with CA-AKI than HA-AKI met RIFLE failure criterion (43.8 vs. 29.1%, p0.001). By 3 years, no differences were found for the individual primary and secondary outcomes tested (all p0.05).CA-AKI was found to be considerably more common than HA-AKI and had similar long-term consequences.
Databáze: OpenAIRE
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