Exenatide Treatment Causes Suppression of Serum Ghrelin Levels following Mixed Meal Test in Obese Diabetic Women
Autor: | Deniz Sigirli, Sinem Kiyici, Gurcan Kisakol, Sinan Cavun, Figen Topyildiz, Metin Guclu, Zulfiye Gul |
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Přispěvatelé: | Uludağ Üniversitesi/Tıp Fakültesi/Eczacılık Anabilim Dalı., Uludağ Üniversitesi/Tıp Fakültesi/Biyoistatistik Anabilim Dalı., Gül, Zülfiye, Sıgırlı, Deniz, Çavun, Sinan, AAF-9939-2020, AAA-7472-2021, AAC-9702-2019 |
Jazyk: | angličtina |
Rok vydání: | 2016 |
Předmět: |
Weight loss
Blood sampling Endocrinology Diabetes and Metabolism medicine.medical_treatment Antidiabetic agent Time factor lcsh:Diseases of the endocrine glands. Clinical endocrinology Ghrelin Receptors Acyltransferases Eating Glycemic control 0302 clinical medicine Endocrinology Hypoglycemic agents Insulin 030212 general & internal medicine Treatment outcome Middle aged Down-regulation Endocrinology & metabolism Priority journal Area under the curve digestive oral and skin physiology Postprandial period Incretin Metformin Ghrelin Clinical trial Blood Cerebrospinal fluid Combination drug therapy Body mass Peptide Cross-sectional studies Waist circumference Female medicine.symptom Research Article Human medicine.drug Adult medicine.medical_specialty Article Subject Clinical article Weight reduction Research & experimental medicine Drug therapy combination 030209 endocrinology & metabolism Down regulation Incretins Article Treatment duration Glp-1 03 medical and health sciences Plasma ghrelin Internal medicine Diabetes mellitus Exendin 4 medicine Humans Obesity Medicine research & experimental Test meal Prospective study Cross-sectional study lcsh:RC648-665 Drug effects Postprandial state Exendin-4 Venoms business.industry Time factors Type 2 Diabetes Mellitus Diabetes mellitus type 2 Weight medicine.disease GHRL protein human Venom Gastric-acid-secretion Biological marker Glucose Therapies Exenatide Non insulin dependent diabetes mellitus Peptides Hormone blood level business Prospective studies Complication Biomarkers |
Zdroj: | Journal of Diabetes Research, Vol 2016 (2016) Journal of Diabetes Research |
ISSN: | 2314-6745 |
DOI: | 10.1155/2016/1309502 |
Popis: | Aim. To investigate the effect of exenatide treatment on serum ghrelin levels in obese female patients with type 2 diabetes mellitus.Methods. Fourteen female patients with type 2 diabetes mellitus being treated with metformin and exenatide were enrolled. A mixed meal test was applied to the patients while continuing with their daily medications. Blood samples were taken before and at 60, 120, and 180 minutes following mixed meal test to measure serum total ghrelin, glucose, and insulin levels. The following week, exenatide treatment of the patients was paused for 24 hours and the same experimental procedures were repeated.Results. Serum ghrelin levels were suppressed significantly at 180 minutes with exenatide treatment compared with baseline (294.4±57.5versus234.5±59.4 pg/mL) (p<0.001). Serum ghrelin levels at 180 minutes were statistically different when percentage change in serum ghrelin levels after mixed meal tests with and without exenatide usage were compared (p=0.001). Estimated total area under the curve values for serum ghrelin concentrations was also significantly lower with exenatide compared with omitted treatment (p=0.035).Conclusion. These results suggest that the effect of exenatide on weight loss may be related with the suppression of serum ghrelin levels, which is an orexigenic peptide. |
Databáze: | OpenAIRE |
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