Exenatide Treatment Causes Suppression of Serum Ghrelin Levels following Mixed Meal Test in Obese Diabetic Women

Autor: Deniz Sigirli, Sinem Kiyici, Gurcan Kisakol, Sinan Cavun, Figen Topyildiz, Metin Guclu, Zulfiye Gul
Přispěvatelé: Uludağ Üniversitesi/Tıp Fakültesi/Eczacılık Anabilim Dalı., Uludağ Üniversitesi/Tıp Fakültesi/Biyoistatistik Anabilim Dalı., Gül, Zülfiye, Sıgırlı, Deniz, Çavun, Sinan, AAF-9939-2020, AAA-7472-2021, AAC-9702-2019
Jazyk: angličtina
Rok vydání: 2016
Předmět:
Weight loss
Blood sampling
Endocrinology
Diabetes and Metabolism
medicine.medical_treatment
Antidiabetic agent
Time factor
lcsh:Diseases of the endocrine glands. Clinical endocrinology
Ghrelin Receptors
Acyltransferases
Eating
Glycemic control
0302 clinical medicine
Endocrinology
Hypoglycemic agents
Insulin
030212 general & internal medicine
Treatment outcome
Middle aged
Down-regulation
Endocrinology & metabolism
Priority journal
Area under the curve
digestive
oral
and skin physiology
Postprandial period
Incretin
Metformin
Ghrelin
Clinical trial
Blood
Cerebrospinal fluid
Combination drug therapy
Body mass
Peptide
Cross-sectional studies
Waist circumference
Female
medicine.symptom
Research Article
Human
medicine.drug
Adult
medicine.medical_specialty
Article Subject
Clinical article
Weight reduction
Research & experimental medicine
Drug therapy
combination
030209 endocrinology & metabolism
Down regulation
Incretins
Article
Treatment duration
Glp-1
03 medical and health sciences
Plasma ghrelin
Internal medicine
Diabetes mellitus
Exendin 4
medicine
Humans
Obesity
Medicine
research & experimental
Test meal
Prospective study
Cross-sectional study
lcsh:RC648-665
Drug effects
Postprandial state
Exendin-4
Venoms
business.industry
Time factors
Type 2 Diabetes Mellitus
Diabetes mellitus
type 2
Weight
medicine.disease
GHRL protein
human
Venom
Gastric-acid-secretion
Biological marker
Glucose
Therapies
Exenatide
Non insulin dependent diabetes mellitus
Peptides
Hormone blood level
business
Prospective studies
Complication
Biomarkers
Zdroj: Journal of Diabetes Research, Vol 2016 (2016)
Journal of Diabetes Research
ISSN: 2314-6745
DOI: 10.1155/2016/1309502
Popis: Aim. To investigate the effect of exenatide treatment on serum ghrelin levels in obese female patients with type 2 diabetes mellitus.Methods. Fourteen female patients with type 2 diabetes mellitus being treated with metformin and exenatide were enrolled. A mixed meal test was applied to the patients while continuing with their daily medications. Blood samples were taken before and at 60, 120, and 180 minutes following mixed meal test to measure serum total ghrelin, glucose, and insulin levels. The following week, exenatide treatment of the patients was paused for 24 hours and the same experimental procedures were repeated.Results. Serum ghrelin levels were suppressed significantly at 180 minutes with exenatide treatment compared with baseline (294.4±57.5versus234.5±59.4 pg/mL) (p<0.001). Serum ghrelin levels at 180 minutes were statistically different when percentage change in serum ghrelin levels after mixed meal tests with and without exenatide usage were compared (p=0.001). Estimated total area under the curve values for serum ghrelin concentrations was also significantly lower with exenatide compared with omitted treatment (p=0.035).Conclusion. These results suggest that the effect of exenatide on weight loss may be related with the suppression of serum ghrelin levels, which is an orexigenic peptide.
Databáze: OpenAIRE
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