Mesenchymal Stem Cells: A Trump Card for the Treatment of Diabetes?
| Autor: | Arianna Scuteri, Elisabetta Donzelli |
|---|---|
| Přispěvatelé: | Donzelli, E, Scuteri, A |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
insulin Medicine (miscellaneous) Type 2 diabetes Review type-2 diabetes Regenerative medicine General Biochemistry Genetics and Molecular Biology BIO/16 - ANATOMIA UMANA Diabetes mellitus Type-1 diabete medicine Immune Diseases Intensive care medicine lcsh:QH301-705.5 Type-2 diabete Mesenchymal stem cell Type 1 diabetes mesenchymal stem cells business.industry medicine.disease lcsh:Biology (General) pancreatic islets transplantation type-1 diabetes immune suppression business Adult stem cell |
| Zdroj: | Biomedicines Biomedicines, Vol 8, Iss 112, p 112 (2020) |
| ISSN: | 2227-9059 |
| Popis: | The advent of the new revolutionary approach based on regenerative medicine is progressively reshaping the therapeutic scenario of many different diseases, such as cardiovascular diseases and immune diseases, with encouraging results. During the last 10 years, many studies have also proposed the use of mesenchymal stem cells (MSCs), adult stem cells with several interesting properties already used in different experimental models, for the treatment of diabetes, however, reporting conflicting outcomes. These reasons have given rise to a question: are these cells a real trump card for the biomedical field? Are they really able to outclass the traditional therapies, or at least able to give an advantage over them? In this review, we will discuss the most promising results obtained with MSCs for the treatment of diabetes and its complications, we will compare the different therapeutic treatments applied as well as the most likely mechanisms of action, and overall we will give an in-depth overview of the pros and the cons of the use of MSCs for the therapy of both type-1 and type-2 diabetes. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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