Reduced expression of a gene proliferation signature is associated with enhanced malignancy in colon cancer
| Autor: | Anthony E. Reeve, Mark Thompson-Fawcett, Sarah Song, Michael A. Black, Jan Friederichs, Han-Seung Yoon, Bernhard Holzmann, Ahmad Anjomshoaa, Ryuji Fukuzawa, John L. McCall, Bostjan Humar, A.M. van Rij, Yu-Hsin Lin |
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| Rok vydání: | 2009 |
| Předmět: |
Male
Cancer Research disease-free survival Colorectal cancer Colon proliferation signature Biology Malignancy Bioinformatics Cohort Studies Immunoenzyme Techniques Breast cancer Gene expression medicine Biomarkers Tumor Tumor Cells Cultured Humans RNA Messenger Gene Cell Proliferation Oligonucleotide Array Sequence Analysis Regulation of gene expression Cell growth Reverse Transcriptase Polymerase Chain Reaction Gene Expression Profiling Genetics and Genomics Middle Aged medicine.disease Prognosis Gene expression profiling Gene Expression Regulation Neoplastic Oncology colon cancer Colonic Neoplasms Cancer research Female |
| Zdroj: | British Journal of Cancer |
| ISSN: | 0007-0920 |
| Popis: | The association between cell proliferation and the malignant potential of colon cancer is not well understood. Here, we evaluated this association using a colon-specific gene proliferation signature (GPS). The GPS was derived by combining gene expression data obtained from the analysis of a cancer cell line model and a published colon crypt profile. The GPS was overexpressed in both actively cycling cells in vitro and the proliferate compartment of colon crypts. K-means clustering was used to independantly stratify two cohorts of colon tumours into two groups with high and low GPS expression. Notably, we observed a significant association between reduced GPS expression and an increased likelihood of recurrence (P |
| Databáze: | OpenAIRE |
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