Genetic diversity and evolution of Hare Calicivirus (HaCV), a recentlyidentified lagovirus fromLepus europaeus

Autor: Clément Droillard, Jacques Le Pendu, Stéphane Marchandeau, Marina Chatel, Ghislaine Le Gall-Reculé, Agnès Quéméner, François-Xavier Briand, Evelyne Lemaitre, Nicolas Eterradossi, Jean-Sébastien Guitton
Přispěvatelé: QUEMENER, Agnès, Unité Virologie, Immunologie, Parasitologie Avaires et Cunicoles (VIPAC), Laboratoire de Ploufragan-Plouzané-Niort [ANSES], Agence nationale de sécurité sanitaire de l'alimentation, de l'environnement et du travail (ANSES)-Agence nationale de sécurité sanitaire de l'alimentation, de l'environnement et du travail (ANSES), Centre de Recherche en Cancérologie et Immunologie Nantes-Angers (CRCINA), Université d'Angers (UA)-Université de Nantes (UN)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Centre hospitalier universitaire de Nantes (CHU Nantes), Unité Petite Faune Sédentaire et Espèces Outre-Mer [Nantes] (Office Français de la Biodiversité - OFB), Unité de Virologie, Immunologie, Parasitologie Avaires et Cunicoles [Ploufragan] (ANSES - Laboratoire de Ploufragan-Plouzané-Niort), Agence nationale de sécurité sanitaire de l'alimentation, de l'environnement et du travail (ANSES), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN)-Centre hospitalier universitaire de Nantes (CHU Nantes)-Centre National de la Recherche Scientifique (CNRS)-Université d'Angers (UA)
Jazyk: angličtina
Rok vydání: 2020
Předmět:
0301 basic medicine
Microbiology (medical)
Most recent common ancestor
Lepus europaeus
viruses
[SDV]Life Sciences [q-bio]
030106 microbiology
Microbiology
03 medical and health sciences
fluids and secretions
Genotype
Calicivirus
Genetics
[SDV.BID.EVO] Life Sciences [q-bio]/Biodiversity/Populations and Evolution [q-bio.PE]
Animals
Molecular Biology
Gene
Ecology
Evolution
Behavior and Systematics
Phylogeny
Caliciviridae Infections
Genetic diversity
HaCV
Hare
biology
Phylogenetic tree
Strain (biology)
Lagovirus
[SDV.BID.EVO]Life Sciences [q-bio]/Biodiversity/Populations and Evolution [q-bio.PE]
Genetic evolution
Genetic Variation
virus diseases
biology.organism_classification
Hares
Biological Evolution
[SDV] Life Sciences [q-bio]
030104 developmental biology
Infectious Diseases
Evolutionary biology
France
VP60 capsid protein structural model
Zdroj: Infection, Genetics and Evolution
Infection, Genetics and Evolution, 2020, pp.104310. ⟨10.1016/j.meegid.2020.104310⟩
Infection, Genetics and Evolution, Elsevier, 2020, pp.104310. ⟨10.1016/j.meegid.2020.104310⟩
ISSN: 1567-1348
1567-7257
Popis: International audience; First recognized as highly pathogenic viruses, hare lagoviruses belonging to genotype GII.1 (EBHSV) infect various Lepus species. Genetically distinct benign lagoviruses (Hare Calicivirus, HaCV) have recently been identified but few data have been available so far on these strains. The analysis of 199 samples from hunted hares collected throughout France allowed the detection of 20 HaCV and showed that they were widely distributed in this country. Ten HaCV capsid protein gene sequences were characterized. A first HaCV capsid protein structural model was proposed, revealing a global structure similar to that of a pathogenic GII.1 strain. The HaCV sequences showed an even higher genetic diversity than previously appreciated, with the characterization of two genotypes (GII.2, GII.3) and several additional putative genotypes. The most recent common ancestor for HaCV VP60 gene was estimated to be much older than that for GII.1 pathogenic strains. These results give new insights into the phylogenetic relationships of HaCV within the Lagovirus genus.
Databáze: OpenAIRE
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