A neonatal nonhuman primate model of gestational Zika virus infection with evidence of microencephaly, seizures and cardiomyopathy

Autor:	Craig N. Kreklywich, Christopher J. Parkins, Robert L. Schelonka, John V. Brigande, Lisa A Houser, Anne D. Lewis, Jessica L. Smith, Brandy L. Dozier, Meredith A. Kelleher, Marjorie R. Grafe, Terry K. Morgan, Victoria H. J. Roberts, Lauren Renner, Xiaojie Wang, Alec J. Hirsch, Heidi L. Pecoraro, Trevor J. McGill, Peter Stenzel, Travis Hodge, Jonathan R. Lindner, Rosemary J. Steinbach, Daniel N. Streblow, Lois M. A. Colgin, Takeshi F. Andoh, Martha Neuringer, Nicole N. Haese, Jonah B. Sacha, Edward Porsov, Christopher D. Kroenke, Rhonda MacAllister, Antonio E. Frias, J. Beth Kempton, Robert M. Friedman, Justin M. Greene
Jazyk:	angličtina
Rok vydání:	2020
Předmět:	0301 basic medicine RNA viruses Pediatrics Embryology Maternal Health Placenta Monkeys Pathology and Laboratory Medicine Macaque Miscarriage Zika virus Purkinje Cells 0302 clinical medicine Animal Cells Pregnancy Medicine and Health Sciences 030212 general & internal medicine Pregnancy Complications Infectious Neurons Mammals Multidisciplinary biology Zika Virus Infection Obstetrics and Gynecology Eukaryota Animal Models 3. Good health Rhesus macaque Experimental Organism Systems Medical Microbiology Viral Pathogens Viruses Vertebrates Microcephaly Medicine Gestation Female medicine.symptom Pathogens Cellular Types Anatomy Cardiomyopathies Research Article Primates medicine.medical_specialty Hearing loss Science Research and Analysis Methods Microbiology 03 medical and health sciences Fetus Seizures biology.animal Old World monkeys medicine Animals Microbial Pathogens Biology and life sciences Flaviviruses Rhesus Monkeys business.industry Euthanasia Organisms Reproductive System Neonates Zika Virus Cell Biology biology.organism_classification medicine.disease Macaca mulatta Disease Models Animal Pregnancy Trimester First 030104 developmental biology Cellular Neuroscience Amniotes Animal Studies Women's Health business Developmental Biology Neuroscience
Zdroj:	PLoS ONE PLoS ONE, Vol 15, Iss 1, p e0227676 (2020)
ISSN:	1932-6203
Popis:	Zika virus infection during pregnancy is associated with miscarriage and with a broad spectrum of fetal and neonatal developmental abnormalities collectively known as congenital Zika syndrome (CZS). Symptomology of CZS includes malformations of the brain and skull, neurodevelopmental delay, seizures, joint contractures, hearing loss and visual impairment. Previous studies of Zika virus in pregnant rhesus macaques (Macaca mulatta) have described injury to the developing fetus and pregnancy loss, but neonatal outcomes following fetal Zika virus exposure have yet to be characterized in nonhuman primates. Herein we describe the presentation of rhesus macaque neonates with a spectrum of clinical outcomes, including one infant with CZS-like symptoms including cardiomyopathy, motor delay and seizure activity following maternal infection with Zika virus during the first trimester of pregnancy. Further characterization of this neonatal nonhuman primate model of gestational Zika virus infection will provide opportunities to evaluate the efficacy of pre- and postnatal therapeutics for gestational Zika virus infection and CZS.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aaab45a3b00f516b98f0f268430f1dc5 http://europepmc.org/articles/PMC6959612 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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