Cardiovascular characterization of SD-3211, a novel benzothiazine calcium channel blocker, in isolated rabbit hearts
| Autor: | Tatsuji Furuta, Hideyasu Yamauchi, Tadashi Iso, Nobuaki Miyawaki, Tatsuro Shigei |
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| Rok vydání: | 1991 |
| Předmět: |
Cardiac function curve
Male medicine.drug_class Nicardipine Vasodilation Calcium channel blocker Pharmacology Cardiovascular System General Biochemistry Genetics and Molecular Biology Diltiazem Coronary Circulation medicine Animals Channel blocker General Pharmacology Toxicology and Pharmaceutics business.industry Heart General Medicine Calcium Channel Blockers Myocardial Contraction Perfusion Thiazoles Anesthesia Circulatory system cardiovascular system Female Coronary vasodilator Rabbits business medicine.drug |
| Zdroj: | Life sciences. 48(20) |
| ISSN: | 0024-3205 |
| Popis: | The cardiovascular effects of SD-3211, a novel benzothiazine Ca++ channel blocker, were compared with those of diltiazem and nicardipine in Langendorff-perfused rabbit hearts. SD-3211 was more potent in increasing coronary artery flow than in depressing cardiac function (i.e., contractile force, heart rate and conduction time). The relative specificity of SD-3211 for coronary vasodilation to cardiodepression was clearly greater than that of diltiazem, but less than that of nicardipine. Thus, the present study demonstrates that SD-3211, despite a non-dihydropyridine type of Ca++ channel blocker, can be characterized as a potent coronary vasodilator with a little effect on cardiac function. |
| Databáze: | OpenAIRE |
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