The association between interleukin-28B gene polymorphisms as a potential biomarker and the risk of chronic Periodontitis in an Iranian population
| Autor: | Bita Moudi, Mehrnoosh Moudi, Zahra Heidari, Hamidreza Mahmoudzadeh-Sagheb |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Adult
Genetic Markers Male 0301 basic medicine medicine.medical_specialty Pathology lcsh:Specialties of internal medicine Population Single-nucleotide polymorphism Iran Polymorphism Single Nucleotide Risk Assessment Severity of Illness Index Gastroenterology 03 medical and health sciences Predictive Value of Tests Reference Values lcsh:RC581-951 Internal medicine medicine Humans SNP Genetic Predisposition to Disease Allele Polymorphism education General Dentistry education.field_of_study business.industry Incidence Interleukins Research Haplotype Case-control study Middle Aged medicine.disease Chronic periodontitis Interleukin-28B (IL-28B) Chronic Periodontitis (CP) 030104 developmental biology Otorhinolaryngology Case-Control Studies Chronic Periodontitis Female Interferons Neurology (clinical) business SNP array |
| Zdroj: | Head & Face Medicine, Vol 13, Iss 1, Pp 1-8 (2017) Head & Face Medicine |
| DOI: | 10.1186/s13005-017-0148-y |
| Popis: | Chronic Periodontitis (CP) is a common inflammatory disease affects supporting tissues of the teeth and can lead to tooth loss. The objective of this study was to determine the relationship between polymorphisms in the IL-28B gene and chronic periodontitis in an Iranian population. Two hundred and ten CP patients and one hundred healthy subjects were enrolled in the present case-control study. The rs12979860 and rs8099917 SNPs were identified using RFLP and T-ARMS-PCR methods respectively. SNP analysis revealed that the G allele of rs8099917 SNP and T allele of rs12979860 SNP increased susceptibility to CP compared to the A allele and C allele (p |
| Databáze: | OpenAIRE |
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