Heterogeneous methodology of racial/ethnic classification may be responsible for the different risk assessments for prostate cancer between Black and White men in Brazil
| Autor: | Rui M. Almeida, Frederico R. Romero, Renato Tambara Filho, Antonio W. Romero, Luiz Ricardo T P Xavier, Jorge Eduardo Fouto Matias |
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| Rok vydání: | 2013 |
| Předmět: |
Male
medicine.medical_specialty Multivariate analysis Prostate biopsy Epidemiology Urology Biopsy Black People lcsh:RC870-923 Risk Assessment White People Prostate cancer Reference Values Risk Factors medicine Prevalence Humans medicine.diagnostic_test business.industry Prostate Cancer Prostatic Neoplasms Race Relations Middle Aged Prostate-Specific Antigen lcsh:Diseases of the genitourinary system. Urology medicine.disease Relative risk Multivariate Analysis Original Article Risk assessment business Brazil Demography Ethnology |
| Zdroj: | International Brazilian Journal of Urology : official journal of the Brazilian Society of Urology International Brazilian Journal of Urology, Vol 41, Iss 2, Pp 360-366 (2015) International braz j urol v.41 n.2 2015 International Braz J Urol Sociedade Brasileira de Urologia (SBU) instacron:SBU International braz j urol, Volume: 41, Issue: 2, Pages: 360-366, Published: APR 2015 |
| ISSN: | 1677-6119 |
| Popis: | Objectives To evaluate if the different results of prostate cancer risk between black and white Brazilian men may be associated with the varying methodology used to define participants as either Blacks or Whites. Patients and Methods We evaluated median PSA values, rate of PSA level ≥4.0 ng/mL, indications for prostate biopsy, prostate cancer detection rate, biopsy/cancer rate, cancer/biopsy rate, and the relative risk of cancer between blacks versus whites, blacks versus non-blacks (browns and whites), non-whites (browns and blacks) versus whites, African versus non-African descendants, and African descendants or blacks versus non-African descendants and non-blacks. Results From 1544 participants, there were 51.4% whites, 37.2% browns, 11.4% blacks, and 5.4% African descendants. Median PSA level was 0.9 ng/mL in whites, browns, and non-African descendants, compared to 1.2 ng/mL in blacks, and African descendants or blacks, and 1.3 ng/mL in African descendants. Indications for prostate biopsy were present in 16.9% for African descendants, 15.9% of black, 12.3% of white, 11.4% for non-African descendants, and 9.9% of brown participants. Prostate cancer was diagnosed in 30.3% of performed biopsies: 6.2% of African descendants, 5.1% of blacks, 3.3% of whites, 3.0% of non-African descendants, and 2.6% of browns. Conclusions Median PSA values were higher for Blacks versus Whites in all classification systems, except for non-white versus white men. The rate of prostate biopsy, prostate cancer detection rate, and relative risk for cancer was increased in African descendants, and African descendants or blacks, compared to non-African descendants, and non-African descendants and non-blacks, respectively. |
| Databáze: | OpenAIRE |
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