Increased Mortality in Narcolepsy
| Autor: | Maurice M. Ohayon, Mark Eller, Chinglin Lai, Arun Bhattacharyya, Diane Guinta, Jed Black |
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| Rok vydání: | 2014 |
| Předmět: |
Adult
Male medicine.medical_specialty Pediatrics Adolescent Population Psychological intervention Decile Young Adult Cause of Death Physiology (medical) medicine Humans Young adult Psychiatry education Aged Narcolepsy Retrospective Studies Cause of death education.field_of_study business.industry Mortality rate Retrospective cohort study Middle Aged medicine.disease United States Female Neurology (clinical) business Mortality in Narcolepsy |
| Zdroj: | Sleep. 37:439-444 |
| ISSN: | 1550-9109 0161-8105 |
| DOI: | 10.5665/sleep.3470 |
| Popis: | Objective To evaluate the mortality rate in patients with narcolepsy. Design Data were derived from a large database representative of the US population, which contains anonymized patient-linked longitudinal claims for 173 million individuals. Setting Symphony Health Solutions (SHS) Source Lx, an anonymized longitudinal patient dataset. Patients/participants All records of patients registered in the SHS database between 2008 and 2010. Interventions None. Measurements and results Identification of patients with narcolepsy was based on ≥ 1 medical claim with the diagnosis of narcolepsy (ICD-9 347.xx) from 2002 to 2012. Dates of death were acquired from the Social Security Administration via a third party; the third party information was encrypted in the same manner as the claims data such that anonymity is ensured prior to receipt by SHS. Annual all-cause mortality rates for 2008, 2009, and 2010 were calculated retrospectively for patients with narcolepsy and patients without narcolepsy in the database, and standardized mortality ratios (SMR) were calculated. Mortality rates were also compared with the general US population (Centers for Disease Control data). SMRs of the narcolepsy population were consistent over the 3-year period and showed an approximate 1.5-fold excess mortality relative to those without narcolepsy. The narcolepsy population had consistently higher mortality rates relative to those without narcolepsy across all age groups, stratified by age decile, from 25-34 years to 75+ years of age. The SMR for females with narcolepsy was lower than for males with narcolepsy. Conclusions Narcolepsy was associated with approximately 1.5-fold excess mortality relative to those without narcolepsy. While the cause of this increased mortality is unknown, these findings warrant further investigation. |
| Databáze: | OpenAIRE |
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