Desialylation Decreases the Resistance of Apo B-Containing Lipoproteins to Aggregation and Increases Their Atherogenic Potential
| Autor: | Alexandra A. Melnichenko, O. A. Ivanova, I. V. Suprun, V.V. Kaplun, Alexander N. Orekhov, O. M. Panasenko, E. V. Popov, Igor A. Sobenin, Vladimir V. Tertov, D. V. Aksenov |
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| Rok vydání: | 2005 |
| Předmět: |
medicine.medical_specialty
Very low-density lipoprotein Apolipoprotein B Lipoproteins Newcastle disease virus Neuraminidase Blood lipids Lipoproteins VLDL Sialidase Muscle Smooth Vascular General Biochemistry Genetics and Molecular Biology chemistry.chemical_compound Internal medicine medicine Humans Apolipoproteins B Intermediate-density lipoprotein Analysis of Variance biology Cholesterol General Medicine Atherosclerosis N-Acetylneuraminic Acid In vitro Sialic acid Endocrinology Lipoproteins IDL Biochemistry chemistry cardiovascular system biology.protein lipids (amino acids peptides and proteins) |
| Zdroj: | Bulletin of Experimental Biology and Medicine. 140:51-54 |
| ISSN: | 1573-8221 0007-4888 |
| DOI: | 10.1007/s10517-005-0409-9 |
| Popis: | Subfractions of apo B-containing lipoproteins (VLDL and intermediate-density lipoproteins) with reduced content of sialic acid were found in human blood. These lipoproteins are characterized by high capacity to spontaneous association (aggregation) and stimulated accumulation of cholesterol in smooth muscle cells of human aortic intima. In vitro treatment of apo B-containing lipoproteins with alpha-2,6-sialidase and alpha-2,3-sialidase stimulated aggregation and increased the ability of these particles to potentiate cholesterol accumulation in smooth muscle cells of the intact human aortic intima. Probably, desialylation of various apo B-containing lipoproteins can occur in the blood; this process decreases their resistance to aggregation, and increases the ability of these particles to stimulate accumulation of cholesterol in human aortic intima cells, i.e. increases their atherogenic potential. |
| Databáze: | OpenAIRE |
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