Altered cytokine levels in the blood and cerebrospinal fluid of chronic pain patients
| Autor: | Kathleen Schell, Daniel Muller, Miroslav Backonja, Christopher L. Coe |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
Adult
Blood Glucose Male medicine.medical_treatment Immunology Pain Cerebrospinal fluid medicine Humans Immunology and Allergy Pain Measurement Analysis of Variance business.industry Chronic pain Interleukin Middle Aged medicine.disease Glucose Cytokine Neurology Chronic Disease Neuropathic pain Neuralgia Cytokines Female Tumor necrosis factor alpha Neurology (clinical) business Polyneuropathy |
| Zdroj: | Journal of Neuroimmunology. 195:157-163 |
| ISSN: | 0165-5728 |
| DOI: | 10.1016/j.jneuroim.2008.01.005 |
| Popis: | This study replicates and extends prior reports of abnormal cytokine levels in chronic pain patients and has correlated the alterations with pain severity. In addition, there appeared to be a need to directly assess cerebrospinal fluid (CSF) because previous findings on cytokine concentrations in peripheral circulation have been inconsistent. CSF and blood specimens were obtained from 14 patients with distal painful non-diabetic polyneuropathy (DPPN) or post-traumatic neuralgia (PTN). Elevated receptor levels for Tumor Necrosis Factor (sTNFr) were the most distinctive abnormality along with low interleukin-10 (IL-10). sTNFr in CSF and blood, and IL-1s in CSF, were positively associated with pain intensity, whereas IL-10 in both compartments was inversely correlated with pain symptoms. An imbalance of pro- and anti-inflammatory cytokines appears to be a clinically relevant feature, which may contribute to the maintenance of chronic pain. |
| Databáze: | OpenAIRE |
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