How Does the Level of Nerve Root Resection in En Bloc Sacrectomy Influence Patient-Reported Outcomes?

Autor: Joseph H. Schwab, Michael J. Yaszemski, Francis J. Hornicek, Patrick J. Boland, Olivier van Wulfften Palthe, Matthew T. Houdek, John H. Healey, Franklin H. Sim, Peter S. Rose
Rok vydání: 2016
Předmět:
Male
Sports medicine
medicine.medical_treatment
Health Status
Neurosurgical Procedures
CORR Insights
Disability Evaluation
0302 clinical medicine
Interquartile range
Colostomy
Orthopedics and Sports Medicine
Orthopedic Procedures
Defecation
Pain Measurement
Aged
80 and over
Pain
Postoperative
General Medicine
Middle Aged
Mental Health
Treatment Outcome
030220 oncology & carcinogenesis
Female
Spinal Nerve Roots
Adult
medicine.medical_specialty
Sacrum
Nerve root
Adolescent
Sexual Behavior
03 medical and health sciences
Young Adult
Predictive Value of Tests
medicine
Chordoma
Humans
Patient Reported Outcome Measures
Aged
Spinal Neoplasms
business.industry
Recovery of Function
medicine.disease
United States
Surgery
business
Sexual function
Gastrointestinal Motility
030217 neurology & neurosurgery
Zdroj: Clinical orthopaedics and related research. 475(3)
ISSN: 1528-1132
Popis: For patients with sacral tumors, who are well enough for surgery, en bloc resection is the preferred treatment. Survival, postoperative complications, and recurrent rates have been described, but patient-reported outcomes often are not included in these studies. The purposes of this study were (1) to compare patient-reported outcomes after en bloc sacrectomy, based on the level of sacral nerve root resection, in terms of mental health, physical health, bowel function, and sexual function; and (2) to assess differences in terms of mental health, physical health, and pain between patients with and without a colostomy. A total of 74 patients, of whom 58 (78%) were diagnosed with chordoma, were surveyed between February 2012 and October 2014. This represented 48% of patients with sacral chordoma who were alive and who had been treated with a transverse sacral resection between June 2000 and August 2013 at three institutions with a minimum followup of 6 months (mean, 59 months; range, 6–255 months). We chose 6 months because we believe that neurologic deficits generally are stable by this point and that patients generally have recovered from the operation by this time. Patients were divided into five groups based on the most caudal nerve root spared: L5 (N = 10), S1 (N = 22), S2 (N = 17), S3 (N = 18), and S4 (N = 7). Only postoperative outcomes were collected using the National institute of Health’s Patient Reported Measurement Information System (PROMIS) Global Health survey, PROMIS Pain Interference survey, PROMIS Pain Intensity survey, PROMIS Sexual Function survey, and the Modified Obstruction and Defecation Score survey. Differences between two adjacent levels were found in terms of mental health, physical health, and sexual function. Patients in whom the S2 nerve roots were spared had a lower mental health score (median = 44, interquartile range [IQR] = 41–51) than patients in whom the S3 nerve roots were spared (median = 53, IQR = 48–56, q = 0.049). Patients in whom the S2 nerve roots were spared had a slightly lower physical health score (median = 42, IQR = 40–51) than patients in whom the S3 nerve roots were spared (median = 47, IQR = 45–54, q = 0.043). Patients in whom the S1 roots were spared (median = 1.0, range = 1.0–1.0) had a lower orgasm score than patients in whom the S2 nerve roots were spared (median = 3, range = 2–5, q = 0.027). No differences in terms of mental health, physical health, or pain were found between the colostomy group and the no colostomy group. The combination of our findings can be used to further educate patients and discuss expectations. In an operative setting, these data can be considered when deciding to place a colostomy. Level III, therapeutic study.
Databáze: OpenAIRE
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