Long non-coding RNA LINC00472 inhibits oral squamous cell carcinoma via miR-4311/GNG7 axis
| Autor: | Chen, Zou, Xiaozhi, Lv, Haigang, Wei, Siyuan, Wu, Jing, Song, Zhe, Tang, Shiwei, Liu, Xia, Li, Yilong, Ai |
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| Rok vydání: | 2022 |
| Předmět: |
Squamous Cell Carcinoma of Head and Neck
Bioengineering General Medicine Applied Microbiology and Biotechnology Gene Expression Regulation Neoplastic MicroRNAs Head and Neck Neoplasms Cell Line Tumor GTP-Binding Protein gamma Subunits Carcinoma Squamous Cell Humans Mouth Neoplasms RNA Long Noncoding Cell Proliferation Biotechnology |
| Zdroj: | Bioengineered. 13:6371-6382 |
| ISSN: | 2165-5987 2165-5979 |
| DOI: | 10.1080/21655979.2022.2040768 |
| Popis: | Emerging studies indicate that long non-coding RNAs play important roles in oral squamous cell carcinoma (OSCC). However, the function of the majority of long non-coding RNAs is still unclear. Recently, LINC00472 has been reported to play crucial roles in multiple cancers. However, the role of LINC00472 in oral squamous cell carcinoma (OSCC) is still not clear. This study found that LncRNA LINC00472 was significantly down-regulated in several squamous cell carcinoma cancer tissues and OSCC cell lines. Over-expression of LINC00472 in OSCC cells inhibited OSCC progression and alleviated OSCC immune responses. Additionally, we confirmed that LINC00472 functioned as an hsa-miR-4311 sponge and regulated the expression of GNG7 (guanine nucleotide-binding protein, gamma 7). Also, we found that LINC00472 over-expression could suppress xenograft tumor growth in |
| Databáze: | OpenAIRE |
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