Evaluation of CD38 expression in Sudanese patients with chronic lymphocytic leukemia

Autor: Tarig H Merghani, Eldirdiri M. Abdel Rahman, Enaam Abdelrhman Abdelgader, Osama Ali Altayeb, Nada Hassan Eltayeb, Tasniem Ahmed Eltahir, Eman Abbass Fadul
Rok vydání: 2018
Předmět:
Adult
Male
0301 basic medicine
medicine.medical_specialty
Chronic lymphocytic leukemia
lcsh:Medicine
Physical examination
Disease
Disease cluster
General Biochemistry
Genetics and Molecular Biology
Immunophenotyping
Sudan
03 medical and health sciences
0302 clinical medicine
hemic and lymphatic diseases
Internal medicine
medicine
Humans
Cutoff
lcsh:Science (General)
lcsh:QH301-705.5
Aged
Aged
80 and over
Leukemia
Membrane Glycoproteins
Flowcytometer
medicine.diagnostic_test
business.industry
lcsh:R
General Medicine
Middle Aged
Flow Cytometry
Prognosis
medicine.disease
ADP-ribosyl Cyclase 1
Leukemia
Lymphocytic
Chronic
B-Cell
Research Note
Cd38 expression
Cross-Sectional Studies
030104 developmental biology
lcsh:Biology (General)
030220 oncology & carcinogenesis
Female
business
CD38
CLL
lcsh:Q1-390
Zdroj: BMC Research Notes
BMC Research Notes, Vol 11, Iss 1, Pp 1-6 (2018)
ISSN: 1756-0500
Popis: Objective The objective of this study was to evaluate the cluster of differentiation-38 (CD38) expression in Sudanese patients with chronic lymphocytic leukemia (CLL) and to determine its association with clinical and laboratory characteristics of the disease. Results We conducted a cross-sectional study on 99 patients diagnosed with CLL in Khartoum Oncology Hospital in Khartoum, Sudan. Immunophenotyping and CD38 expression levels were measured with four-color flowcytometry. The results of physical examination and blood analyses were used for assigning a modified Rai clinical staging system. The collected data were analyzed using the Statistical Package for the Social Science, version 22 (SPSS Inc., Chicago, IL, USA). According to our findings, the frequencies of 7%, 20%, and 30% cutoff levels of CD38 expressions were 68.7%, 41.4%, and 36.4% respectively. CD38 cutoff level of 7% showed a significant association with hemoglobin concentration (P = 0.04), whereas other cutoff levels showed insignificant results. All the three cutoff levels showed insignificant associations with the other clinical and laboratory variables. In conclusion, the CD38 expression at a cutoff level of 7% seems to be more valuable clinically than higher cutoff levels in Sudanese CLL patients.
Databáze: OpenAIRE
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