Fully automated classification of bone marrow infiltration in low-dose CT of patients with multiple myeloma based on probabilistic density model and supervised learning
| Autor: | Jan Kybic, Zuzana Meckova, Lukas Lambert, Francisco Martínez-Martínez |
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| Rok vydání: | 2016 |
| Předmět: |
Male
medicine.medical_specialty Density model Health Informatics computer.software_genre 030218 nuclear medicine & medical imaging Machine Learning 03 medical and health sciences 0302 clinical medicine Voxel Image Processing Computer-Assisted Humans Medicine Femur Neoplasm Metastasis Multiple myeloma Aged Ground truth business.industry Supervised learning Probabilistic logic Middle Aged medicine.disease Computer Science Applications medicine.anatomical_structure 030220 oncology & carcinogenesis Female Bone marrow Radiology Bone Marrow Neoplasms Multiple Myeloma Tomography X-Ray Computed business computer |
| Zdroj: | Computers in Biology and Medicine. 71:57-66 |
| ISSN: | 0010-4825 |
| Popis: | This paper presents a fully automated method for the identification of bone marrow infiltration in femurs in low-dose CT of patients with multiple myeloma. We automatically find the femurs and the bone marrow within them. In the next step, we create a probabilistic, spatially dependent density model of normal tissue. At test time, we detect unexpectedly high density voxels which may be related to bone marrow infiltration, as outliers to this model. Based on a set of global, aggregated features representing all detections from one femur, we classify the subjects as being either healthy or not. This method was validated on a dataset of 127 subjects with ground truth created from a consensus of two expert radiologists, obtaining an AUC of 0.996 for the task of distinguishing healthy controls and patients with bone marrow infiltration. To the best of our knowledge, no other automatic image-based method for this task has been published before. |
| Databáze: | OpenAIRE |
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