Alloimmune neonatal neutropenia in monozygous twins. High-dose intravenous gammaglobulin therapy
| Autor: | Atsuko Matsumura, Akihiko Kinugasa, Takuma Shikata, Naoko Yoshida, Yasuo Doi, Mitsuko Miyamoto, Tadashi Sawada, Kenji Saito, Shigeyuki Sudo, Hisashi Tsujii |
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| Rok vydání: | 1991 |
| Předmět: |
Male
Neutropenia Neutrophils Monozygotic twin Fluorescent Antibody Technique Immunoglobulins Autoimmune Diseases Isoantibodies Leukocyte Count hemic and lymphatic diseases Diseases in Twins Medicine Humans Alloimmune neonatal neutropenia Indirect immunofluorescence Leukopenia biology business.industry Immunization Passive Infant Newborn Intravenous gammaglobulin General Medicine Twins Monozygotic medicine.disease Flow Cytometry Pediatrics Perinatology and Child Health Immunology biology.protein Antibody medicine.symptom business |
| Zdroj: | Acta paediatrica Scandinavica. 80(1) |
| ISSN: | 0001-656X |
| Popis: | An indirect immunofluorescence test using a flow cytometer (FACS420) was useful for detection of antineutrophil antibodies (anti-NA2 antibodies) in a case of monozygous twins with alloimmune neonatal neutropenia. When high-dose intravenous gammaglobulin (300 mg/kg for five consecutive days) was given to one twin, the increase in neutrophils was not obvious. Although neutropenia persisted for about three months, no infections were observed in either of the twins. |
| Databáze: | OpenAIRE |
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