Comparison of neurologic outcome after deep hypothermic circulatory arrest with alpha-stat and pH-stat cardiopulmonary bypass in newborn pigs
| Autor: | C. Dean Kurth, Irene B. O'Hara, Margaret A. Priestley, Jeffrey A. Golden, John McCann |
|---|---|
| Jazyk: | angličtina |
| Předmět: |
Pulmonary and Respiratory Medicine
Resuscitation Swine Hemodynamics Brain damage Hematocrit law.invention Central nervous system disease Random Allocation law medicine Cardiopulmonary bypass Animals Neurologic Examination Cardiopulmonary Bypass medicine.diagnostic_test business.industry Carbon Dioxide Hydrogen-Ion Concentration medicine.disease Oxygen Treatment Outcome Blood pressure Animals Newborn Anesthesia Models Animal Heart Arrest Induced Deep hypothermic circulatory arrest Brain Damage Chronic Surgery medicine.symptom Cardiology and Cardiovascular Medicine business Psychomotor Performance |
| Zdroj: | The Journal of Thoracic and Cardiovascular Surgery. (2):336-343 |
| ISSN: | 0022-5223 |
| DOI: | 10.1067/mtc.2001.112338 |
| Popis: | Objective: Deep hypothermic circulatory arrest for neonatal heart surgery poses the risk of brain damage. Several studies suggest that pH-stat management during cardiopulmonary bypass improves neurologic outcome compared with alpha-stat management. This study compared neurologic outcome in a survival piglet model of deep hypothermic circulatory arrest between alpha-stat and pH-stat cardiopulmonary bypass. Methods: Piglets were randomly assigned to alpha-stat (n = 7) or pH-stat (n = 7) cardiopulmonary bypass, cooled to 19°C brain temperature, and subjected to 90 minutes of deep hypothermic circulatory arrest. After bypass rewarming/reperfusion, they survived 2 days. Neurologic outcome was assessed by neurologic performance (0-95, 0 = no deficit and 95 = brain death) and functional disability scores, as well as histopathology. Arterial pressure, blood gas, glucose, and brain temperature were recorded before, during, and after bypass. Results: All physiologic data during cardiopulmonary bypass were similar between groups (pH-stat vs alpha-stat) except arterial pH (7.06 ± 0.03 vs 7.43 ± 0.09, P |
| Databáze: | OpenAIRE |
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