Work in progress: reduction of calcium activity by radiopaque contrast media
| Autor: | Thomas W. Morris, L G Sahler, M. R. Violante, Harry W. Fischer |
|---|---|
| Rok vydání: | 1983 |
| Předmět: |
Sodium
Inorganic chemistry Contrast Media Iothalamate Meglumine chemistry.chemical_element Diatrizoate In Vitro Techniques Calcium Iodine Dissociation (chemistry) Iopamidol Electrolytes chemistry.chemical_compound Sodium citrate Electrochemistry Animals Humans Medicine Radiology Nuclear Medicine and imaging Diatrizoate Meglumine business.industry Osmolar Concentration Angiography Metrizoic Acid Iothalamic Acid chemistry Ionic strength business medicine.drug |
| Zdroj: | Radiology. 148:55-59 |
| ISSN: | 1527-1315 0033-8419 |
| DOI: | 10.1148/radiology.148.1.6856865 |
| Popis: | An in vitro examination of the effects of radiopaque contrast media anions, cations, additives, and ionic strength on ionic calcium level using ion-specific electrodes was made. The calcium-binding additives sodium citrate and sodium EDTA produced the largest reduction in ionic calcium. At the same iodine concentration the anions diatrizoate, iothalamate, metrizoate, and ioxaglate reduced ionic calcium by essentially the same amount. Sodium compounds reduced ionic calcium more than did meglumine compounds, a difference that is probably related to dissociation. The nonionic compounds iohexol and iopamidol did not reduce ionic calcium significantly. Ionic strength appears to have little direct effect on ionic calcium at and above physiologic levels. All ionic contrast media bind significant amounts of ionic calcium at the high concentrations achieved during selective arteriography. Since the anions are only weak calcium binders supplemental calcium can restore the level of ionic calcium. |
| Databáze: | OpenAIRE |
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