Long-Term Outcomes of Carinal Sleeve Resection in Non-Small Cell Lung Cancer
| Autor: | Seyyit Ibrahim Dincer, Mehmet Ali Bedirhan, Salih Bilen, Celalettin Ibrahim Kocaturk, Cem Emrah Kalafat, Levent Cansever, Celal Bugra Sezen |
|---|---|
| Přispěvatelé: | İstinye Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Kocaturk, Celalettin Ibrahim |
| Rok vydání: | 2019 |
| Předmět: |
Adult
Male Pulmonary and Respiratory Medicine medicine.medical_specialty Lung Neoplasms Time Factors medicine.medical_treatment Bronchopleural fistula Bronchi 030204 cardiovascular system & hematology 03 medical and health sciences Pneumonectomy Postoperative Complications 0302 clinical medicine Risk Factors Carcinoma Non-Small-Cell Lung medicine Carcinoma Humans Neoplasm Invasiveness Lung cancer Central Tumors Aged Retrospective Studies Carinal Resection business.industry Mortality rate Sleeve Lobectomy Induction chemotherapy Retrospective cohort study Middle Aged medicine.disease Non-Small Cell Lung Cancer Surgery Trachea Treatment Outcome 030228 respiratory system Lobectomy Female Cardiology and Cardiovascular Medicine business |
| Zdroj: | The Thoracic and Cardiovascular Surgeon. 68:190-198 |
| ISSN: | 1439-1902 0171-6425 |
| Popis: | Background Carinal resections for non-small cell lung cancer (NSCLC) invading the carina are challenging cases that require a therapeutic strategy. The aim of this study was to compare the oncologic outcomes and complications of patients who underwent carinal resection. Methods Sixty-four patients who underwent carinal resection between 2005 and 2016 were evaluated. Data were retrospectively reviewed for indications, complications, and factors influencing long-term survival. Results The study included 51 patients (79.7%) who underwent sleeve pneumonectomy (sP) and 13 patients who underwent carinal sleeve lobectomy (csL) as a curative therapy. Nine patients (14.1%) received induction chemotherapy. Complications were observed in 31 patients (48.8%), including 24 patients (47.1%) in the sP group and 7 patients (53.8%) in the csL group (p = 0.662). Six patients (9.4%) developed bronchopleural fistula. The 30-day mortality rate was 10.9% (n = 7). The 5- and 10-year survival rates were 42.2 and 23.1%, respectively. N2 and R1 were identified as factors affecting survival (p = 0.029 and p = 0.047). Conclusion Carinal resections have acceptable morbidity, mortality, and long-term survival outcomes in central NSCLC. The main factors affecting survival are complete resection and nodal status. The results of csL were similar to those of sP. Therefore, we believe that csL should be performed in all eligible patients. |
| Databáze: | OpenAIRE |
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