Protective effects of cyclooxygenase-2 inhibitors on narrow-band ultraviolet B-irradiated epidermal Ia+ Langerhans cells and Thy-1+ dendritic epidermal T cells in mice
| Autor: | Hong-Duo Chen, Yakun Wang, Chang-Long Tai, Yan Wu, Fang He, Yuming Zhao, Huachen Wei |
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| Rok vydání: | 2008 |
| Předmět: |
Ultraviolet Rays
medicine.medical_treatment Indomethacin Biology Biochemistry Islets of Langerhans Mice Fluorescence microscope medicine Animals Dietary supplementation Cyclooxygenase Inhibitors Irradiation Physical and Theoretical Chemistry skin and connective tissue diseases Mice Inbred BALB C Sulfonamides integumentary system Immunosuppression Ultraviolet b General Medicine Molecular biology Narrow band Celecoxib Langerhans Cells Immunology biology.protein Pyrazoles Female Cyclooxygenase Epidermis medicine.drug |
| Zdroj: | Photochemistry and photobiology. 84(2) |
| ISSN: | 0031-8655 |
| Popis: | Cyclooxygenase (COX)-2 inhibitors are known to be used as chemopreventative agents against certain malignancies. Thus far, there has been very limited information on whether COX-2 inhibitors protect against chronic narrow-band UVB (NB-UVB)-induced immunosuppression. The present study investigated the effect of nonselective and specific COX-2 inhibitors, indomethacin and celecoxib, on epidermal Ia + Langerhans cells (LCs) and Thy-1 + dendritic epidermal T cells (DETCs) in mice irradiated with NB-UVB. Sixty female BALB/c mice were divided randomly into the control group (sham) and the experimental groups (irradiated with NB-UVB for 17 weeks, further divided into five groups according to the diets containing different concentrations of either COX-2 inhibitors). Alterations in the density and morphology of epidermal Ia + LCs and Thy-1 + DETCs in mice were documented using fluorescence microscopy. Chronic NB-UVB irradiation substantially decreased the density and altered the morphology of the epidermal Ia + LCs and Thy-1 + DETCs in control mice. The dietary supplementation of both COX-2 inhibitors displayed a dosage-dependent protective effect on the murine dendritic cells irradiated by NB-UVB. In conclusion, COX-2 inhibitors protected against chronic NB-UVB-induced density and morphologic changes in epidermal Ia + LCs and Thy-1 + DETCs in mice. |
| Databáze: | OpenAIRE |
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