Bone mineral density in children with celiac disease. Effect of a Gluten-free diet
| Autor: | Carlos Mautalen, A Roca, S De Rosa, C Tau, X Valenzuela |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
Male
musculoskeletal diseases medicine.medical_specialty Adolescent Glutens Bone density Medicine (miscellaneous) Disease Gastroenterology Coeliac disease Absorptiometry Photon Bone Density Internal medicine medicine Humans Longitudinal Studies Prospective Studies Child Prospective cohort study Bone mineral Nutrition and Dietetics business.industry Body Weight Infant musculoskeletal system medicine.disease Body Height Osteopenia Celiac Disease Endocrinology El Niño Child Preschool Female Gluten free business |
| Zdroj: | European Journal of Clinical Nutrition. 60:358-363 |
| ISSN: | 1476-5640 0954-3007 |
| DOI: | 10.1038/sj.ejcn.1602323 |
| Popis: | To assess the degree of osteopenia in children with celiac disease (CD) at the time of diagnosis and the effect of a gluten-free diet (GFD).Longitudinal and prospective study.In total, 24 children (18 girls, six boys) diagnosed with CD by means of an intestinal biopsy were included in the study. Mean+/-s.d. age was 4.9+/-4.3 years. In all, 16 patients were under (2.20+/-0.82 year) and eight were over the age of 4 years (10.30+/-2.90 year). The time between the first symptoms and diagnosis was 17.30+/-24.70 months (range: 2-109 months). Spine bone mineral content (BMC), area and bone mineral density (BMD) were measured by DXA at baseline and 1.17+/-0.93 years after GFD.Before treatment, mean+/-s.d. BMD was 0.46+/-0.13 g/cm(2), the BMD Z-score was -1.36+/-1.20, and was below -1 s.d. in 14 patients (58%). BMC, area and BMD increased significantly on GFD. BMD increased from 0.46+/-0.13 to 0.55+/-0.13 g/cm(2) (P0.001). BMD Z-score improved from -1.36+/-1.20 to -0.23+/-1.20 after GFD. However, BMD increased more than 1 s.d. in 15 of the 16 children under the age of 4 years, a similar increase was only observed in four of the eight children aged more than 4 years, some of whom did not follow GFD strictly. Height and weight increased significantly with GFD (P0.001) and the increase correlated positively with the increase in BMD.Axial BMD below -1 s.d. was found in 58% of children with celiac disease. Axial bone mass reverted to normal values in most children under the age of 4, who had low bone mass, all of whom followed GFD strictly. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|