Modulation of KCNQ4 channel activity by changes in cell volume
| Autor: | Charlotte Hougaard, Søren-Peter Olesen, Else K. Hoffmann, Dan A. Klaerke, Nanna K. Jorgensen |
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| Rok vydání: | 2004 |
| Předmět: |
Indoles
Patch-Clamp Techniques Potassium Channels Pyridines G protein Biophysics Protein tyrosine phosphatase Phenylenediamines Biochemistry Cell Line KCNQ3 Potassium Channel Potassium Channel Blockers Humans KCNQ2 Potassium Channel PKA Patch clamp PKC Protein Kinase C Cell Size KCNQ Potassium Channels Voltage-gated ion channel Kinase Chemistry Osmolar Concentration HEK 293 cells Cell Biology Cyclic AMP-Dependent Protein Kinases Potassium channel Tyrosine phosphatase Cell biology Potassium Channels Voltage-Gated KCNQ2/3 Calcium Cell swelling Carbamates Intracellular Signal Transduction |
| Zdroj: | Biochimica et Biophysica Acta (BBA) - Biomembranes. 1660:1-6 |
| ISSN: | 0005-2736 |
| Popis: | KCNQ4 channels expressed in HEK 293 cells are sensitive to cell volume changes, being activated by swelling and inhibited by shrinkage, respectively. The KCNQ4 channels contribute significantly to the regulatory volume decrease (RVD) process following cell swelling. Under isoosmotic conditions, the KCNQ4 channel activity is modulated by protein kinases A and C, G protein activation, and a reduction in the intracellular Ca2+ concentration, but these signalling pathways are not responsible for the increased channel activity during cell swelling. |
| Databáze: | OpenAIRE |
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