Autophagy drives plasticity and functional polarization of tumor-associated macrophages
| Autor: | Wan-Ting Kuo, Jia-Ming Chang, Chih Peng Chang, Chien-Chin Chen, Nina Tsao |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_treatment
Clinical Biochemistry Macrophage polarization Cellular homeostasis Biology Biochemistry stomatognathic system Cancer immunotherapy Neoplasms Tumor-Associated Macrophages Genetics medicine Autophagy Tumor Microenvironment Humans skin and connective tissue diseases Molecular Biology Tumor microenvironment Inflammasome Cell Biology Tumor progression Cancer research Cytokine secretion Immunotherapy hormones hormone substitutes and hormone antagonists medicine.drug |
| Zdroj: | IUBMB lifeREFERENCES. 74(2) |
| ISSN: | 1521-6551 |
| Popis: | Tumor-associated macrophages (TAMs) are a major component of the tumor microenvironment (TME) and are key cells in regulating tumor development, metastasis, immune responses, inflammation, and chemoresistance. In response to TME stimulation, circulating monocytes are recruited and differentiated as TAMs. Most TAMs are defined as alternatively activated (M2) phenotype to create immunosuppressive TME and support tumor progression. In contrast, classically activated (M1) TAMs can produce pro-inflammatory cytokines and enhance immune responses against tumor development. Autophagy is a conserved catabolic process to control cellular homeostasis and biological function. Emerging evidence reveals crucial contribution of autophagy in modulating TAM plasticity and functional polarization in TME. In this review, we introduce the current understanding of autophagy-regulated TAM function in development of cancer. We focus on how autophagy modulates antigen presentation, LC3-associated phagocytosis, cytokine secretion, inflammasome regulation, recruitment, differentiation, and polarization of TAMs and suggest strategies for potential therapeutics by targeting autophagy in TAMs. We expect this review can provide a new notion of future cancer immunotherapy. |
| Databáze: | OpenAIRE |
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