Contribution of sulfate-reducing bacteria to homeostasis disruption during intestinal inflammation
| Autor: | Cláudia Mara Lara Melo Coutinho, Vanessa Ribeiro Figliuolo, Robson Coutinho-Silva |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Inflammation Disease Biology Inflammatory bowel disease General Biochemistry Genetics and Molecular Biology Immune tolerance 03 medical and health sciences 0302 clinical medicine Immune system Immune Tolerance medicine Animals Homeostasis Humans Intestinal Mucosa General Pharmacology Toxicology and Pharmaceutics Sulfur-Reducing Bacteria General Medicine Inflammatory Bowel Diseases medicine.disease Intestines 030104 developmental biology Interaction with host 030220 oncology & carcinogenesis Immunology Disease Progression medicine.symptom Dysbiosis |
| Zdroj: | Life Sciences. 215:145-151 |
| ISSN: | 0024-3205 |
| Popis: | Alteration in microbial populations and metabolism are key events associated with disruption of intestinal homeostasis and immune tolerance during intestinal inflammation. A substantial imbalance in bacterial populations in the intestine and their relationships with the host have been observed in patients with inflammatory bowel disease (IBD), believed to be part of an intricate mechanism of triggering and progression of intestinal inflammation. Because elevated numbers of sulfate-reducing bacteria (SRB) have been found in the intestines of patients with IBD, the study of their interaction with intestinal cells and their potential involvement in IBD has been the focus of investigation to better understand the intestinal pathology during IBD, as well as to find new ways to treat the disease. SRB not only directly interact with intestinal epithelial cells during intestinal inflammation but may also promote intestinal damage through generation of hydrogen sulfide at high levels. Herein we review the literature to discuss the various aspects of SRB interaction with host intestinal tissue, focusing on their interaction with intestinal epithelial and immune cells during intestinal inflammation. |
| Databáze: | OpenAIRE |
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