Radiation dose and breast cancer risk in patients treated for cancer of the cervix
| Autor: | G. Engholm, Antonio Bosch, N. Won Choi, Brian MacMahon, D Robson, D. H. Thomson, Edward T. Krementz, Paola Pisani, James A. Merrill, Maria Koch, Nancy Kreiger, George B. Hutchison, M.H. Pejovic, John D. Boice, Dorothy Robb, Patricia Fraser, Kjell E. Kjorstad, Frank Neal, Donald F. Austin, Lester J. Peters, Elisabet Björkholm, Arja Rimpelä, Cm Janine Bell, Howard B. Latourette, Hans H. Storm, Folke Pettersson, Linda C. Harlan, Vera Pompe Kirn, Jean Wactawski, Maria Blettner, Hanna Stankusova, Milford D. Schulz, Hermann Lisco, H. Lochmuller, Ruth A. Kleinerman, P. Prior, Kristjan Sigurdsson, T. Gregory Hislop, Dietrich von Fournier, Marilyn Stovall, Michel P Coleman, Rolf Frischkorn |
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| Rok vydání: | 1989 |
| Předmět: |
Adult
Oncology Cancer Research medicine.medical_specialty Neoplasms Radiation-Induced medicine.medical_treatment Population Uterine Cervical Neoplasms Breast Neoplasms 030218 nuclear medicine & medical imaging 03 medical and health sciences 0302 clinical medicine Breast cancer Risk Factors Internal medicine medicine Carcinoma Humans Risk factor education Cervix Aged Gynecology Cervical cancer education.field_of_study Radiotherapy business.industry Ovary Age Factors Cancer Dose-Response Relationship Radiation Radiotherapy Dosage Middle Aged medicine.disease 3. Good health Radiation therapy medicine.anatomical_structure 030220 oncology & carcinogenesis Female business |
| Zdroj: | International Journal of Cancer. 44:7-16 |
| ISSN: | 1097-0215 0020-7136 |
| DOI: | 10.1002/ijc.2910440103 |
| Popis: | The relationship between breast cancer and radiation treatment for cervical cancer was evaluated in an international study of 953 women who subsequently developed breast cancer and 1,806 matched controls. Radiation doses to the breast (average 0.31 Gy) and ovaries (average 32 Gy) were reconstructed for exposed subjects on the basis of their original radiotherapy records. Overall, 88% of the breast cancer cases and 89% of the controls received radiation treatment [relative risk (RR) = 0.88; 95% confidence interval (CI) = 0.7-1.2]. Among women with intact ovaries (561 cases, 1,037 controls), radiotherapy was linked to a significant 35% reduction in breast cancer risk, attributable in all likelihood to the cessation of ovarian function. Ovarian doses of 6 Gy were sufficient to reduce breast cancer risk but larger doses did not reduce risk further. This saturation-type response is probably due to the killing of a critical number of ovarian cells. Cervical cancer patients without ovaries (145 cases, 284 controls) were analyzed separately because such women are at especially low natural risk for breast cancer development. In theory, any effect of low-dose breast exposure, received incidentally during treatment for cervical cancer, should be more readily detectable. Among women without ovaries, there was a slight increase in breast cancer risk (RR = 1.07; 95% CI = 0.6-2.0), and a suggestion of a dose response with the RR being 1.0, 0.7, 1.5 and 3.1 for breast doses of 0, 0.01-0.24, 0.25-0.49 and 0.50+ Gy, respectively. However, this trend of increasing RR was not statistically significant. If low-dose radiation increases the risk of breast cancer among women over age 40 years, it appears that the risk is much lower than would be predicted from studies of younger women exposed to higher doses. |
| Databáze: | OpenAIRE |
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