Optimized release of dexamethasone and gentamicin from a soluble ocular insert for the treatment of external ophthalmic infections
| Autor: | Vincent Baeyens, Jean-Luc Veuthey, L. Balant, Bernard Boisrame, Marianne Gex-Fabry, Emmanuel Varesio, Vassilios Kaltsatos, Marc Fathi, Robert Gurny |
|---|---|
| Rok vydání: | 1998 |
| Předmět: |
Male
Eye Infections/drug therapy medicine.drug_class Anti-Inflammatory Agents/administration & dosage medicine.medical_treatment Eye Infections Anti-Inflammatory Agents Pharmaceutical Science Dexamethasone/administration & dosage/pharmacokinetics Pharmacology Dexamethasone ddc:616.89 Drug Delivery Systems Anti-Bacterial Agents/administration & dosage medicine Animals Antibacterial agent ddc:615 Gentamicins/administration & dosage/pharmacokinetics business.industry Aminoglycoside Eye drop Eye infection Anti-Bacterial Agents Gentamicin Sulfate Anesthesia Corticosteroid Gentamicin Rabbits Gentamicins business medicine.drug |
| Zdroj: | Journal of Controlled Release, Vol. 52, No 1-2 (1998) pp. 215-20 |
| ISSN: | 0168-3659 |
| DOI: | 10.1016/s0168-3659(97)00212-5 |
| Popis: | In the case of external ophthalmic infections, repeated instillations of antibiotics are required to reach therapeutic level, above the minimal inhibitory concentration (MIC). An additional administration of a corticosteroid is often needed, in order to limit the precorneal damages caused by the infection. However, repeated administration of a corticosteroid can increase intraocular pressure and thus lead to glaucoma. To overcome the disadvantages of separated and repeated instillations of two products and to avoid the side effects of dexamethasone, a soluble insert containing gentamicin sulfate and dexamethasone phosphate was developed. The new system ensures the concomitant release of the two drugs during the first 10 h of treatment, followed by an adequate concentration of gentamicin sulfate, above the MIC of 4.0 microgram ml-1, during 50 h, due to a combination of gentamicin sulfate with cellulose acetate phthalate, which reduces the solubility of gentamicin. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect