Stachybotrydial Selectively Enhances Fibrin Binding and Activation of Glu-plasminogen
| Autor: | Keiji Hasumi, Masaaki Sasaoka, Yasuko Wada |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
Fibrin binding
medicine.medical_treatment Metabolite Molecular Conformation Glu-Plasminogen Plasminogen Activators chemistry.chemical_compound Stachybotrys Fibrinolytic Agents Drug Discovery Fibrinolysis Mole medicine Humans Spiro Compounds Fibrinolysin Biotransformation Benzofurans Pharmacology Fibrin Chemistry Plasminogen Urokinase-Type Plasminogen Activator Peptide Fragments Stachybotrydial Selective modulation Biochemistry Tissue Plasminogen Activator Function (biology) Protein Binding |
| Zdroj: | The Journal of Antibiotics. 60:674-681 |
| ISSN: | 1881-1469 0021-8820 |
| DOI: | 10.1038/ja.2007.86 |
| Popis: | Stachybotrydial, a triprenyl phenol metabolite from a fungus, has a plasminogen modulator activity selective to Glu-plasminogen. Stachybotrydial enhanced fibrin binding and activation of Glu-plasminogen (2- to 4-fold enhancement at 60� 120 m M) but not of Lys-plasminogen. Approximately 1.2� 1.6 moles of ( 3 H)stachybotrydial bound to Glu-plasminogen to exert such effects. The selective modulation of the Glu- plasminogen function by stachybotrydial may be related to alteration of its conformational status. |
| Databáze: | OpenAIRE |
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