Effect of Specific Antibodies on Chronic Echovirus Type 5 Encephalitis in a Patient with Hypogammaglobulinemia
| Autor: | M P Langford, G J Stanton, L. S. Weiner, Randall M. Goldblum, Samuel Baron, Ralph A. Lord, A. S. Goldman, J. T. Howell |
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| Rok vydání: | 1979 |
| Předmět: |
Male
Echovirus Antibodies Viral medicine.disease_cause Virus Hypogammaglobulinemia Plasma Cerebrospinal fluid Agammaglobulinemia Antibody Specificity medicine Humans Immunology and Allergy Blood Transfusion biology business.industry Gamma globulin medicine.disease Virology Enterovirus B Human Titer Infectious Diseases Child Preschool Chronic Disease biology.protein Encephalitis Interferons gamma-Globulins Antibody business |
| Zdroj: | Journal of Infectious Diseases. 140:858-863 |
| ISSN: | 1537-6613 0022-1899 |
| DOI: | 10.1093/infdis/140.6.858 |
| Popis: | The effects of specific antibodies in chronic echovirus type 5 (echo 5) encephalitis were investigated in a patient with x-linked hypogammaglobulinemia. Virus was detected in cerebrospinal fluid (CSF) and blood despite treatment with commercial human gammaglobulin that contained low titers of antibodies to echo 5 (0.6 x 10(4) units per injection). Virus disappeared from blood and CSF when plasma containing high concentrations of antibodies (total dose, 1--4 x 10(4) units/kg) was administered intravenously. Maximal inhibition of virus was achieved in culture and in the patient's CSF when the titer of antibody to echo 5 in CSF was greater than or equal to 16 units/ml. Although the patient died, hyperimmune plasma improved the neurologic status and eliminated detectable virus from the blood and CSF. |
| Databáze: | OpenAIRE |
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