Efficacy of topical tofacitinib in promoting hair growth in non-scarring alopecia: possible mechanism via VEGF induction
| Autor: | Jitlada Meephansan, J. Thummakriengkrai, Werayut Yingmema, Poonkiat Suchonwanit, Saranyoo Ponnikorn, Raksawan Deenonpoe |
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| Rok vydání: | 2017 |
| Předmět: |
Male
Vascular Endothelial Growth Factor A 0301 basic medicine medicine.medical_specialty Administration Topical Inflammation Dermatology Scarring alopecia Biology Mice 03 medical and health sciences chemistry.chemical_compound Piperidines Downregulation and upregulation Internal medicine medicine Animals Pyrroles Protein Kinase Inhibitors Tofacitinib integumentary system Janus Kinase 3 Alopecia General Medicine medicine.disease Mice Inbred C57BL Vascular endothelial growth factor Vascular endothelial growth factor A Pyrimidines 030104 developmental biology Endocrinology chemistry Minoxidil Histopathology medicine.symptom Hair medicine.drug |
| Zdroj: | Archives of Dermatological Research. 309:729-738 |
| ISSN: | 1432-069X 0340-3696 |
| DOI: | 10.1007/s00403-017-1777-5 |
| Popis: | Tofacitinib is a Janus kinase 3 (JAK3) inhibitor that promotes hair growth; however, the efficacy and mechanism of this effect are not yet understood. This study aimed to evaluate the efficacy and mechanism of topical tofacitinib on hair growth in mice. Eight-week-old male C57BL/6 mice were divided equally into four groups and treated topically with tofacitinib, minoxidil, or vehicle once daily for 21 days. Weekly photographs were taken to determine the area and rate of hair growth, and tissue samples were collected for histopathological evaluation. mRNA and protein expression of anagen-maintaining growth factors, including vascular endothelial growth factor (VEGF) and insulin-like growth factor-1 (IGF-1), were determined via RT-PCR and ELISA, respectively. Tofacitinib-treated mice exhibited more hair regrowth than either minoxidil-treated or control mice did between day 7 and 21 (P |
| Databáze: | OpenAIRE |
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