Effects of antihistamines on centrifugal rotation-induced analgesia and conditioned flavor aversions
| Autor: | Diane W. Lee, Kenneth F. Green |
|---|---|
| Rok vydání: | 1989 |
| Předmět: |
Chlorpheniramine
Rotation medicine.medical_treatment Analgesic Drinking Behavior Experimental and Cognitive Psychology Behavioral Neuroscience Saccharin Neurochemical Conditioning Psychological medicine Animals Cimetidine Saline Flavor business.industry Rats Inbred Strains Chlorphenamine Rats Anesthesia Female Antihistamine Analgesia business medicine.drug |
| Zdroj: | Physiology & Behavior. 45:459-464 |
| ISSN: | 0031-9384 |
| DOI: | 10.1016/0031-9384(89)90156-x |
| Popis: | Centrifugal rotation induces short lasting analgesia, as shown in tail flick tests conducted immediately afterwards, and apparently induces visceral upset that can support aversions for flavors ingested immediately beforehand, as indicated in later preference tests. Two experiments were performed with antihistamines to determine whether the analgesic and visceral effects of rotation were attributable to separate neurochemical systems. In each experiment four groups of rats were defined by factorial combination of UCS (rotation at 150 rpm vs. no rotation) and Drug (antihistamine vs. saline). In Experiment 1 the H1 blocker chlorpheniramine (20 mg/kg, IP) was found to be ineffective against analgesia and to block conditioned flavor aversions (CFAs). In Experiment 2 the H2 blocker cimetidine (100 mg/kg, IP) was found to have a nearly significant attenuating effect on analgesia and to have no effect on CFAs. The data support the idea that analgesia and visceral upset are attributable to separate mechanisms, both of which are activated by the same manipulations. |
| Databáze: | OpenAIRE |
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