Toxoplasma gondiiInfection and Mixed Anxiety and Depressive Disorder: A Case-Control Seroprevalence Study in Durango, Mexico
| Autor: | Luis Francisco Sánchez-Anguiano, Oliver Liesenfeld, Jesús Hernández-Tinoco, Alma Rosa Pérez-Álamos, Cosme Alvarado-Esquivel, Isabel Beristain García, Elizabeth Rábago-Sánchez, Gabriel Molotla-de-León, María Nalleli Ortiz-Jurado, Yazmin Elizabeth Torres-Prieto, Luis Omar Berumen-Segovia, Sergio Estrada-Martínez |
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| Rok vydání: | 2016 |
| Předmět: |
Psychiatric patients
medicine.medical_specialty Population Toxoplasma gondii Seroprevalence 03 medical and health sciences 0302 clinical medicine Internal medicine parasitic diseases Medicine education education.field_of_study Mixed anxiety and depressive biology business.industry General Medicine Odds ratio Case-control biology.organism_classification Control subjects Confidence interval 030227 psychiatry Immunology biology.protein Anxiety Original Article Antibody medicine.symptom business 030217 neurology & neurosurgery |
| Zdroj: | Journal of Clinical Medicine Research |
| ISSN: | 1918-3011 1918-3003 |
| Popis: | Background: The parasite Toxoplasma gondii (T. gondii) may invade the brain and might induce behavioral changes. We sought to determine the association of T. gondii infection and mixed anxiety and depressive disorder. Methods: Through an age- and gender-matched case-control seroprevalence study, we examined 65 patients suffering from mixed anxiety and depressive disorder (WHO ICD-10 code: F41.2) attending in a public hospital of mental health and 260 control subjects without this disorder from the general population. Sera of participants were analyzed for anti- Toxoplasma IgG and IgM antibodies using enzyme-linked immunoassays. Results: Fifteen (23.1%) of the 65 patients and 18 (6.9%) of the 260 controls had anti- T. gondii IgG antibodies (odds ratio (OR): 4.03; 95% confidence interval (CI): 1.90 - 8.53; P 150 IU/mL) anti- T. gondii IgG levels was similar in cases and controls (OR: 0.25; 95% CI: 0.05 - 1.06; P = 0.05). Seroprevalence was similar in male cases and controls (P = 1.0); however, seroprevalence was significantly higher in female cases than in female controls (OR: 7.08; 95% CI: 2.83 - 17.67; P < 0.00001). Patients aged 31 - 50 years old had a significantly higher seroprevalence of T. gondii infection than controls of the same age group (OR: 21.04; 95% CI: 5.22 - 84.80; P < 0.00001). Anti- T. gondii IgM antibodies were found in four (26.7%) of the 15 anti- T. gondii IgG seropositive cases and in 10 (55.6%) of the 18 anti- T. gondii IgG seropositive controls (P = 0.15). Conclusions: Results support for the first time an association between seropositivity to T. gondii and mixed anxiety and depressive disorder. Further research to confirm this association and to determine the seroepidemiology of T. gondii infection in patients with this disorder is needed. J Clin Med Res. 2016;8(7):519-523 doi: http://dx.doi.org/10.14740/jocmr2576w |
| Databáze: | OpenAIRE |
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