Biotransformation and detoxification of the neonicotinoid insecticides nitenpyram and dinotefuran by Phanerochaete sordida YK-624
| Autor: | Jianbo Jia, Bing Yan, Hirofumi Hirai, Jianqiao Wang, Hirokazu Kawagishi, Tanaka Yusuke, Toshio Mori, Tangfu Xiao, Haruka Ohno |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Insecticides
010504 meteorology & atmospheric sciences Health Toxicology and Mutagenesis Metabolite Neurotoxins Fungus 010501 environmental sciences Phanerochaete Toxicology Guanidines 01 natural sciences Phanerochaete sordida YK-624 Dinotefuran Neonicotinoids chemistry.chemical_compound Cytochrome P-450 Enzyme System Biotransformation Cell Line Tumor Neurotoxicity Humans Incubation 0105 earth and related environmental sciences Nitenpyram biology Neonicotinoid General Medicine Nitro Compounds biology.organism_classification Pollution Biodegradation Environmental chemistry Biochemistry Inactivation Metabolic Toxicity |
| Zdroj: | Environmental Pollution. 252:856-862 |
| ISSN: | 0269-7491 |
| Popis: | Neonicotinoid insecticides have been widely used throughout the world over the last two decades. In the present study, we investigated the degradation of neonicotinoid insecticides nitenpyram (NIT) and dinotefuran (DIN) by the white-rot fungus Phanerochaete sordida YK-624. While NIT was completely degraded by P. sordida YK-624 under ligninolytic conditions, only a 20% decrease was observed under nonligninolytic conditions. On the other hand, P. sordida YK-624 degraded 31% of DIN under ligninolytic conditions after a 20-day incubation, while it did not degrade DIN under nonligninolytic conditions. We found that cytochromes P450 played a key role in the biotransformation of NIT and DIN by P. sordida YK-624. A novel NIT metabolite (E)-N-((6-chloropyridin-3-yl)methyl)-N-ethyl-N′-hydroxy acetimidamide (CPMHA) and a novel DIN metabolite N-((4aS,7aS,E)-1-methylhexahydrofuro[2,3-d]pyrimidin-2(1H)-ylidene)nitramide (PHPF) were identified in this study. In addition, to evaluate neurotoxicity, the effects of NIT, DIN and their metabolites on the viability of human neuroblastoma cells SH-SY5Y were determined. PHPF showed higher neurological toxicity than DIN, whereas the metabolite of NIT, CPMHA, showed no toxic effect. Our results indicated that the neurological toxicity of NIT could be effectively removed by P. sordida YK-624. |
| Databáze: | OpenAIRE |
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