Cu-Catalyzed Denitrogenative Ring-Opening of 3-Aminoindazoles for the Synthesis of Aromatic Nitrile-Containing (Hetero)Arenes

Autor:	Shaoyu Mai, Shuilin Deng, Qiuling Song, Yao Zhou
Rok vydání:	2018
Předmět:	Nitrile 010405 organic chemistry Chemistry Organic Chemistry 010402 general chemistry Ring (chemistry) 01 natural sciences Biochemistry Combinatorial chemistry 0104 chemical sciences Catalysis chemistry.chemical_compound Reactivity (chemistry) Physical and Theoretical Chemistry Oxidative cleavage
Zdroj:	Organic letters. 20(19)
ISSN:	1523-7052
Popis:	An unprecedented Cu-catalyzed oxidative cleavage of two C–N bonds of 3-aminoindazoles is reported herein, which represents the first example for denitrogenative ring-opening of 3-aminoindazoles. This novel reactivity of 3-aminoindazoles enables the production of diverse aromatic nitrile-containing (hetero)arenes via C–H arylation of (hetero)arenes with wide subsrate scope under mild conditions.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa80b194897acfcdc1c400215b5b3464 https://pubmed.ncbi.nlm.nih.gov/30252489 Zobrazit plný text záznamu