Late-Term Abortion, Stillbirth, and Neonatal Foal Death in Kyrgyzstan: First Isolation of Equine Herpesvirus Type 1 in the Country
| Autor: | Rysbek Nurgaziev, Armando Damiani, Nikolaus Osterrieder, Jailobek Orozov, Irmgard Moser, Maksat Akhmedzhanov |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Streptococcus equi 040301 veterinary sciences Otras Ciencias Biológicas animal diseases Population Abortion Serology Ciencias Biológicas 0403 veterinary science 03 medical and health sciences EHV-1 ABORTION Medicine education education.field_of_study KYRGYZSTAN Equine business.industry MARE Antibody titer Horse 04 agricultural and veterinary sciences Virology Titer 030104 developmental biology Etiology business CIENCIAS NATURALES Y EXACTAS |
| Zdroj: | Journal of Equine Veterinary Science. 51:46-53 |
| ISSN: | 0737-0806 |
| Popis: | Late-term abortion, stillbirth, and neonatal foal mortality (commonly referred to as late fetal losses [LFLs]) of unknown etiology are a serious concern for horse farmers and breeders in Kyrgyzstan. Therefore, we investigated major infectious causes of LFL, with a focus on viral agents, for the first time in the horse population in the country. A total of 221 sera and 149 nasal swabs taken from mares in farms with a history of LFL within 1 year of testing as well as tissue samples collected from 17 LFL cases were investigated. Serologic studies revealed that equine herpesvirus type 1 (EHV-1) and type 4 (EHV-4) were prevalent in the population, although positivity rates were low with neutralizing antibody titers of 1:4 to 1:32 (median 1:8) against both pathogens. High antibody titers in the range from 1:32 to 1:512 (median 1:256) against equine arteritis virus (EAV) were detected in mares on a single farm, whereas three mares from different farms tested positive for Dourine. Virus isolation and PCR investigations of nasal swabs did not suggest ongoing active infection with EHV-1, EHV-4, or EAV in the examined mares. Bacteriologic and virological examination of tissue samples taken from LFL cases revealed the presence of Escherichia coli and/or Streptococcus equi (subsp. zooepidemicus) in 35% of neonatal foal death cases, and EHV-1 was isolated from a late-term abortion case representing the first isolation of this important pathogen of horses in the country and, to the best of our knowledge, in Central Asia. Fil: Akhmedzhanov, Maksat. Freie University Berlin; Alemania. Kyrgyz Research Veterinary Institute; Kirguistán Fil: Nurgaziev, Rysbek. Kyrgyz Research Veterinary Institute; Kirguistán Fil: Orozov, Jailobek. Kyrgyz Research Veterinary Institute; Kirguistán Fil: Moser, Irmgard. Friedrich Loeffler Institut; Alemania Fil: Osterrieder, Nikolaus. Freie University Berlin; Alemania Fil: Damiani, Armando Mario. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina |
| Databáze: | OpenAIRE |
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