Health-related quality of life advantage of long-acting injectable antipsychotic treatment for schizophrenia: a time trade-off study
| Autor: | Rudolf Schrover, Dell Kingsford Smith, Judy Hertel, Andrew Dalton, Richard H. Osborne |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: |
Quality of life
Adult Male medicine.medical_specialty Time Factors Time-trade-off medicine.medical_treatment MEDLINE lcsh:Computer applications to medicine. Medical informatics Injections Intramuscular Drug Administration Schedule Antipsychotic Interviews as Topic Cost of Illness medicine Health Status Indicators Humans Psychiatry Aged Long-acting injection business.industry Research Public Health Environmental and Occupational Health Australia General Medicine Middle Aged medicine.disease Drug Utilization Treatment interval Long acting Treatment Outcome Vignette Social Class Sample size determination Schizophrenia Delayed-Action Preparations Sample Size lcsh:R858-859.7 Female business Antipsychotic Agents |
| Zdroj: | Health and Quality of Life Outcomes Health and Quality of Life Outcomes, Vol 10, Iss 1, p 35 (2012) |
| ISSN: | 1477-7525 |
| Popis: | Background This study was undertaken to estimate utility values for alternative treatment intervals for long acting antipsychotic intramuscular injections for the treatment of schizophrenia. Methods Vignettes were developed using the published literature and an iterative consultation process with expert clinicians and patient representative groups. Four vignettes were developed. The first was a vignette of relapsed/untreated schizophrenia. The other three vignettes presented a standardised picture of well-managed schizophrenia with variations in the intervals between injections: once every 2-weeks, 4-weeks and 3-months. A standardised time trade off (TTO) approach was used to obtain utility values for the vignettes. As a societal perspective was sought, a representative sample of individuals from across the community (Sydney, Australia) was recruited. Ninety-eight people completed the TTO interview. The vignettes were presented in random order to prevent possible ordering effects. Results A clear pattern of increasing utility was observed with increasing time between injections. Untreated schizophrenia was rated as very poor health-related quality of life with a mean (median) utility of 0.27 (0.20). The treated health states were rated at much higher utilities and were statistically significantly different (p < 0.001) from each other: (1) 2-weekly: mean (median) utility = 0.61 (0.65); (2) 4-weekly: mean (median) utility = 0.65 (0.70); (3) 3-monthly: mean (median) utility = 0.70 (0.75). Conclusions This study has provided robust data indicating that approximately a 0.05 utility difference exists between treatment options, with the highest utility assigned to 3-monthly injections. |
| Databáze: | OpenAIRE |
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