Induction chronomodulated chemotherapy plus radiotherapy for nasopharyngeal carcinoma: A Phase II prospective randomized study

Autor: Jin-Hua Long, Yuanyuan Li, Weili Wu, Guoyan Chen, Lina Liu, Xiuyun Gong, Feng Jin, Xiaoxiao Chen, Xiao-xia Gou
Jazyk: angličtina
Rok vydání: 2018
Předmět:
0301 basic medicine
Adult
Male
medicine.medical_specialty
Nausea
medicine.medical_treatment
efficacy
Gastroenterology
lcsh:RC254-282
03 medical and health sciences
0302 clinical medicine
Leukocytopenia
Recurrence
Internal medicine
Antineoplastic Combined Chemotherapy Protocols
medicine
Humans
Chronomodulated chemotherapy
Radiology
Nuclear Medicine and imaging
Neoplasm Metastasis
radiotherapy
Aged
Neoplasm Staging
Cisplatin
Chemotherapy
business.industry
nasopharyngeal carcinoma
toxicities
Induction chemotherapy
General Medicine
Chemoradiotherapy
Induction Chemotherapy
Middle Aged
medicine.disease
Prognosis
lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens
030104 developmental biology
Treatment Outcome
Oncology
Nasopharyngeal carcinoma
030220 oncology & carcinogenesis
Vomiting
Female
medicine.symptom
business
medicine.drug
Follow-Up Studies
Zdroj: Journal of Cancer Research and Therapeutics, Vol 14, Iss 7, Pp 1613-1619 (2018)
ISSN: 1998-4138
0973-1482
Popis: Purpose: The aim of this study was to evaluate the efficacy and toxicities of induction chronomodulated chemotherapy in comparison with conventional induction chemotherapy for nasopharyngeal carcinoma (NPC). Patients and Methods: Between 2003 and 2004, 60 patients with pathologically confirmed NPC were included and randomly assigned to two groups. Patients in the chronomodulated chemotherapy group (n = 30, CC group) received cisplatin at 80 mg/m2 through intravenous infusion from 10:00 to 22:00 and 5-fluorouracil (5-FU) at 1000 mg/m2 plus citrovorum factor at 200 mg/m2 from 22:00 to 10:00 each day for 3 days. Patients in the routine chemotherapy group (n = 30, RC group) received cisplatin infusion within 1 h and 5-FU infusion for about 24 h. The dose in the RC group was the same as that in the CC group. The total irradiation dose in each group was 70 Gy for the whole nasopharynx. Results: One month after induction chemotherapy, the overall response rate was 96.7% in the CC group versus 73.3% in the RC group (P = 0.011). By the end of the 10-year follow-up, 11 patients (36.7%) in the CC group had experienced local recurrence versus 11 patients (36.7%) in the RC group (P > 0.999). The overall survival rates at 1, 5, and 10 years were 96.7%, 53.3%, and 43.3%, respectively, in the CC group, and 96.7%, 43.3%, and 33.3%, respectively, in the RC group (P = 0.346). During induction chemotherapy, the incidence rates of leukocytopenia (43.3% vs. 80%, P = 0.003), thrombocytopenia (26.7% vs. 56.7%, P = 0.018), and nausea/vomiting (40% vs. 66.7%, P = 0.038) were significantly lower in the CC group than in the RC group. The incidence of radiation-induced complications was similar in these two groups. Conclusion: Compared with conventional chemotherapy, induction chrono-chemotherapy seemed to reduce chemotherapy-related toxicities and improve average local relapse time in patients treated with combined chemoradiotherapy for NPC.
Databáze: OpenAIRE
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