Association of glutathione S-transferase M1 and T1 null/present polymorphism with physical performance in the Korean population
| Autor: | Noo Ri Lee, Han Jun Jin, Bit Na Kwon, Seung Hun Han, In Wook Hwang, Eun Ji Choi, Kicheol Kim, Hyung Jun Kim, Hyun Ik，Cho |
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| Rok vydání: | 2018 |
| Předmět: |
Male
0106 biological sciences 0301 basic medicine Multi-stage fitness test medicine.medical_specialty Athletic Performance Peptidyl-Dipeptidase A Biology Polymorphism Single Nucleotide 01 natural sciences Biochemistry Young Adult 03 medical and health sciences Internal medicine Genotype Genetics medicine Chi-square test Humans Actinin Molecular Biology Allele frequency Glutathione Transferase Genetic association Estrogen Receptor alpha Odds ratio 030104 developmental biology Endocrinology Athletes Case-Control Studies Female Analysis of variance Gene polymorphism 010606 plant biology & botany |
| Zdroj: | Genes & Genomics. 41:71-78 |
| ISSN: | 2092-9293 1976-9571 |
| DOI: | 10.1007/s13258-018-0737-6 |
| Popis: | Human physical performance is a highly complex phenotype that is influenced by various factors. In particular, genetic factors related to muscle fiber type, bone density, muscle performance, and metabolic processes are known to contribute in varying degrees to athlete status and physical performance in various ethnic groups. To investigate the relationship between these genetic factors and physical performances, we genotyped five genetic polymorphisms (ACE Ins/Del, ACTN3 R577X, ER-α C/T, GSTM1 null/present, and GSTT1 null/present) in 111 Korean athletes and 145 controls. We examined genotype and allele frequency differences between athletes and control groups, along with the odds ratios, using Chi square. One-way analysis of variance (ANOVA) was used to test the significance of differences in continuous variables between the multiple genetic polymorphisms and physical performance test results. The GSTM1 polymorphism exhibited a highly significant association in athletes (p = 0.017). Combined analysis of GSTM1 and GSTT1 also revealed significant differences between athletes and controls (p |
| Databáze: | OpenAIRE |
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