Severe filamentous fungal infections after widespread tissue damage due to traumatic injury: Six cases and review of the literature
| Autor: | B. Lebeau, Dominique Falcon, Christian Piolat, Odile Faure, Hervé Pelloux, Emmanuelle Bozonnet, Renée Grillot, Philippe Pradel, Axel Aubert, Virginie Vitrat-Hincky |
|---|---|
| Přispěvatelé: | Laboratoire de parasitologie et mycologie, Université Joseph Fourier - Grenoble 1 (UJF)-CHU Grenoble, Deparment of Infectiology and Tropical Diseases, Department of Plastic and Maxillo-Facial Surgery, Surgical Intensive Care Unit, Department of Hand Surgery and Burns, Department of Vascular Surgery, Department of Pediatric General Surgery, Laboratoire Adaptation et pathogénie des micro-organismes [Grenoble] (LAPM), Centre National de la Recherche Scientifique (CNRS)-Université Joseph Fourier - Grenoble 1 (UJF) |
| Jazyk: | angličtina |
| Rok vydání: | 2009 |
| Předmět: |
Microbiology (medical)
Mucorales Adult Male medicine.medical_specialty Necrosis Adolescent medicine.medical_treatment Poison control 03 medical and health sciences Soil 0302 clinical medicine Medicine Humans [SDV.BBM]Life Sciences [q-bio]/Biochemistry Molecular Biology 030212 general & internal medicine Child Mycosis 0303 health sciences Aspergillus General Immunology and Microbiology biology 030306 microbiology business.industry Aspergillus fumigatus Accidents Traffic Fungi General Medicine Middle Aged biology.organism_classification medicine.disease Prognosis Dermatology 3. Good health Surgery Fungicide Infectious Diseases Traumatic injury Amputation Mycoses Mucor Child Preschool Wounds and Injuries Female France medicine.symptom business |
| Zdroj: | Scandinavian Journal of Infectious Diseases Scandinavian Journal of Infectious Diseases, Taylor & Francis, 2009, 41 (6 & 7), pp.491-500. ⟨10.1080/00365540902856537⟩ |
| ISSN: | 0036-5548 |
| DOI: | 10.1080/00365540902856537⟩ |
| Popis: | International audience; We describe 6 cases of severe filamentous fungal infections after widespread tissue damage due to traumatic injury in previously healthy people. Additionally, we report 69 cases from an exhaustive 20-y review of the literature to investigate the epidemiological and clinical features, the prognosis and the therapeutic management of these post-traumatic severe filamentous fungal infections. Traffic (41%) and farm accidents (25%) were the main causes of injury, which involved either the limbs only (41%) or multiple sites (41%). Necrosis was the main symptom (60%) and Mucorales (72%) and Aspergillus (11%) were the 2 most frequent fungi causing infection. These infections required substantial surgical debridement or amputation (96%) associated with aggressive antifungal therapy (81%), depending on the responsible fungi. This study underlines the need for early, repeated and systematic mycological wound samples to guide and adapt surgical and antifungal management in these filamentous fungal infections. |
| Databáze: | OpenAIRE |
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