Decreased cortical octopamine level in basal forebrain lesioned rats: A microdialysis study
| Autor: | Boatell Ml, Nicole Mahy, G. Bendahan |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
Male
medicine.medical_specialty Microdialysis Biology Choline O-Acetyltransferase Rats Sprague-Dawley Lesion chemistry.chemical_compound Prosencephalon Parietal Lobe Biogenic amine Internal medicine medicine Animals Ibotenic Acid Octopamine Chromatography High Pressure Liquid chemistry.chemical_classification Basal forebrain Microchemistry General Neuroscience Homovanillic Acid Octopamine (drug) Hydroxyindoleacetic Acid Choline acetyltransferase Frontal Lobe Rats Endocrinology medicine.anatomical_structure nervous system chemistry Cerebral cortex Anesthesia 3 4-Dihydroxyphenylacetic Acid medicine.symptom Dialysis Ibotenic acid |
| Zdroj: | Neuroscience Letters. 152:45-47 |
| ISSN: | 0304-3940 |
| DOI: | 10.1016/0304-3940(93)90479-5 |
| Popis: | Ibotenic acid-induced lesion of the basal forebrain resulted after 13 days in a 90% reduction of octopamine (OA) in the frontoparietal cortex of adult rats, whereas dihydroxyphenylacetic (DOPAC), homovanillic (HVA) and 5-hydroxyindolacetic (5-HIAA) acids were not modified as measured by microdialysis and high-performance liquid chromatography (HPLC) with electrochemical detection. At this time, cortical choline acetyltransferase (ChAT) activity was decreased by 34%. The results are discussed with respect to possible octopamine involvement in reduced age-associated performance in neurodegenerative processes. |
| Databáze: | OpenAIRE |
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