Predictors of Absent High-grade Cervical Intraepithelial Neoplasia (CIN) in Loop Electrosurgical Excision Procedure Specimens of Patients with Colposcopic Directed Biopsy-Confirmed High-Grade CIN
| Autor: | Komsun Suwannarurk, Araya Sammor, Chamnan Tanprasertkul, Yenrudee Poomtavorn, Yuthadej Thaweekul |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Adult medicine.medical_specialty Biopsy Electrosurgery Papanicolaou stain Uterine Cervical Neoplasms cervical intraepithelial neoplasia Cervical intraepithelial neoplasia Gastroenterology Loop electrosurgical excision procedure 03 medical and health sciences 0302 clinical medicine Predictive Value of Tests Internal medicine medicine Humans neoplasms Colposcopy Vaginal Smears medicine.diagnostic_test business.industry colposcopy virus diseases Retrospective cohort study General Medicine medicine.disease Uterine Cervical Dysplasia female genital diseases and pregnancy complications 030104 developmental biology surgical procedures operative 030220 oncology & carcinogenesis Predictive value of tests High Grade Cervical Intraepithelial Neoplasia Female Neoplasm Grading business Research Article Follow-Up Studies |
| Zdroj: | Asian Pacific Journal of Cancer Prevention : APJCP |
| ISSN: | 2476-762X 1513-7368 |
| Popis: | Objective: To determine predictors of having cervical intraepithelial neoplasia (CIN) 1 or less in loop electrosurgical excision procedure (LEEP) specimens of patients with colposcopic directed biopsy-confirmed CIN 2-3. Methods: Two hundred and eighty patients with colposcopic directed biopsy-confirmed CIN 2-3 who subsequently underwent LEEP were enrolled in the retrospective study. Related clinical data were collected to determine the predictors of CIN 1 or less in LEEP specimens. Results: CIN 1 or less in LEEP specimens was found in 71 (25.4%) of 280 patients. Multivariate logistic regression analyses demonstrated that nulliparity [OR (95% CI) = 3.375 (1.245-9.150)], low grade Papanicolaou (Pap) results [OR (95% CI) = 6.410 (2.877-14.280)] and low grade colposcopic impression [OR (95% CI) = 16.506 (5.844-46.632)] were significant risk factors of having CIN 1 or less in LEEP specimens. Neither persistent nor recurrent CIN 2-3 was detected in 71 patients who had CIN 1 or less in LEEP specimens. However, persistent or recurrent CIN 2-3 developed in 3 out of 209 (1.4%) patients with CIN 2-3 found in LEEP specimens. Conclusion: Approximately 25% of patients with CIN 2-3 in colposcopic directed biopsy specimens had CIN 1 or less found in LEEP specimens. Predicting factors of having CIN 1 or less in LEEP specimens were nulliparity, low grade Pap results and low grade colposcopic impression. |
| Databáze: | OpenAIRE |
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