Sex-dependence and comorbidities of the early-life adversity induced mental and metabolic disease risks: where are we at?
| Autor: | Reemst, Kitty, Ruigrok, Silvie R., Bleker, Laura, Naninck, Eva F.G., Ernst, Tiffany, Kotah, Janssen M., Lucassen, Paul J., Roseboom, Tessa J., Pollux, Bart J.A., de Rooij, Susanne R., Korosi, Aniko |
|---|---|
| Přispěvatelé: | Structural and Functional Plasticity of the nervous system (SILS, FNWI), Epidemiology and Data Science, Obstetrics and Gynaecology, APH - Aging & Later Life, APH - Health Behaviors & Chronic Diseases, ARD - Amsterdam Reproduction and Development, Paediatrics |
| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: |
Male
Cognitive Neuroscience Metabolic health Placenta Rodentia Comorbidity Maternal milk Comorbidities Behavioral Neuroscience Metabolic Diseases Adverse Childhood Experiences Pregnancy Risk Factors Animals Humans Experimental Zoology Rodent Sex-differences Early-life adversity Neuropsychology and Physiological Psychology Experimentele Zoologie WIAS Female Mental health Human |
| Zdroj: | Neuroscience and Biobehavioral Reviews, 138:104627. Elsevier Neuroscience and biobehavioral reviews, 138:104627. Elsevier Limited Neuroscience and Biobehavioral Reviews 138 (2022) Neuroscience and Biobehavioral Reviews, 138 |
| ISSN: | 0149-7634 |
| Popis: | Early-life adversity (ELA) is a major risk factor for developing later-life mental and metabolic disorders. However, if and to what extent ELA contributes to the comorbidity and sex-dependent prevalence/presentation of these disorders remains unclear. We here comprehensively review and integrate human and rodent ELA (pre- and postnatal) studies examining mental or metabolic health in both sexes and discuss the role of the placenta and maternal milk, key in transferring maternal effects to the offspring. We conclude that ELA impacts mental and metabolic health with sex-specific presentations that depend on timing of exposure, and that human and rodent studies largely converge in their findings. ELA is more often reported to impact cognitive and externalizing domains in males, internalizing behaviors in both sexes and concerning the metabolic dimension, adiposity in females and insulin sensitivity in males. Thus, ELA seems to be involved in the origin of the comorbidity and sex-specific prevalence/presentation of some of the most common disorders in our society. Therefore, ELA-induced disease states deserve specific preventive and intervention strategies. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect