Prenatal prediction of neonatal morbidity in survivors with congenital diaphragmatic hernia: a multicenter study
| Autor: | Kypros H. Nicolaides, R. Mazkereth, Laurent Storme, Anne Greenough, Eduard Gratacós, Dick Tibboel, A.F.J. van Heijst, V. Rousseau, Jacques Jani, Alexandra Benachi, J. Matis, Jan Deprest, Karel Allegaert |
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| Přispěvatelé: | Pediatric Surgery |
| Rok vydání: | 2009 |
| Předmět: |
Counseling
Male medicine.medical_specialty Pregnancy Trimester Third Diaphragmatic breathing Gestational Age Prenatal diagnosis Ultrasonography Prenatal Pregnancy medicine Humans Radiology Nuclear Medicine and imaging Hernia Diaphragmatic hernia Lung Hernia Diaphragmatic Fetus Radiological and Ultrasound Technology business.industry Obstetrics Infant Newborn Obstetrics and Gynecology Congenital diaphragmatic hernia Gestational age Functional imaging [IGMD 1] Feeding Behavior General Medicine Tissue engineering and pathology [NCMLS 3] Prognosis medicine.disease Surgery Liver Reproductive Medicine Female Hernias Diaphragmatic Congenital Lung Volume Measurements business Head |
| Zdroj: | Ultrasound in Obstetrics & Gynecology, 33, 64-9 Ultrasound in Obstetrics & Gynecology, 33(1), 64-69. John Wiley & Sons Ltd. Ultrasound in Obstetrics & Gynecology, 33, 1, pp. 64-9 |
| ISSN: | 1469-0705 0960-7692 |
| DOI: | 10.1002/uog.6141 |
| Popis: | Contains fulltext : 81905.pdf (Publisher’s version ) (Closed access) OBJECTIVES: To investigate the value of the observed to expected fetal lung area to head circumference ratio (o/e LHR) and liver position in the prediction of neonatal morbidity in survivors with congenital diaphragmatic hernia (CDH). METHODS: Neonatal morbidity was recorded in 100 consecutive cases with isolated CDH diagnosed in fetal medicine units, which were expectantly managed in the prenatal period, were delivered after 30 weeks and survived until discharge from hospital. Regression analysis was used to identify the significant predictors of morbidity, including prenatal and immediate neonatal findings. RESULTS: The o/e LHR provided significant prediction of the need for prosthetic patch repair, duration of assisted ventilation, need for supplemental oxygen at 28 days, and incidence of feeding problems. An additional independent prenatal predictor of the need for patch repair was the presence of fetal liver in the chest. CONCLUSIONS: In isolated CDH the prenatally assessed size of the contralateral lung is a significant predictor of the need for prosthetic patch repair, the functional consequences of impaired lung development and occurrence of feeding problems. |
| Databáze: | OpenAIRE |
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