Osteoclastogenesis inhibitory factor/osteoprotegerin reduced bone loss induced by mechanical unloading
| Autor: | Youjirou Ichinose, Hiroyuki Tanaka, Masaru Inoue, E. Tsuda, S. Mochizuki, Yoshiki Seino |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
musculoskeletal diseases
Male Deoxypyridinoline medicine.medical_specialty Endocrinology Diabetes and Metabolism Osteoclasts Receptors Cytoplasmic and Nuclear Bone resorption Receptors Tumor Necrosis Factor Bone remodeling Weight-Bearing chemistry.chemical_compound Endocrinology Osteoprotegerin Osteoclast Bone Density Internal medicine medicine Animals Orthopedics and Sports Medicine Femur Tibia Amino Acids Rats Wistar Glycoproteins Bone mineral Phosphorus musculoskeletal system Elasticity Rats Radiography Bone Diseases Metabolic medicine.anatomical_structure chemistry Hindlimb Suspension Calcium Stress Mechanical |
| Zdroj: | Calcified tissue international. 75(4) |
| ISSN: | 0171-967X |
| Popis: | Skeletal unloading resulting from space flight and prolonged immobilization causes bone loss. Such bone loss ostensibly results from a rapid increase in bone resorption and subsequent sustained reduction in bone formation, but this mechanism remains unclear. Osteoclastogenesis inhibitory factor/osteoprotegerin (OCIF/OPG) is a recently identified potent inhibitor of osteoclast formation. We studied effects of OPG administration on tail-suspended growing rats to explore the therapeutic potential of OPG in the treatment and prevention of bone loss during mechanical unloading, such as that which occurs during space flight. Treatment with OPG in tail suspension increased the total bone mineral content (BMC g) of the tibia and femur and the total bone mineral density (BMD g/cm2) of the tibia. Moreover, treatment with OPG prevented reduction not only of BMC and BMD, but also of bone strength occurring through femoral diaphysis. Treatment with OPG in tail-suspended rats improved BMC, BMD and bone strength to levels of normally loaded rats treated with vehicle. Treatment with OPG in normally loaded rats significantly decreased urinary excretion of deoxypyridinoline, but the effect of OPG in tail suspension was unclear. These results indicate that OPG may be useful in inhibiting bone loss-engendered mechanical unloading. |
| Databáze: | OpenAIRE |
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