Proteolytic Control of Lipid Metabolism
| Autor: | Steven M. Claypool, Erica Avery, Pingdewinde N. Sam |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Proteases Protein Conformation Phospholipid Mitochondrion 01 natural sciences Biochemistry Article 03 medical and health sciences chemistry.chemical_compound Organelle Animals Humans Phospholipids Regulation of gene expression 010405 organic chemistry Chemistry Cell Membrane Lipid metabolism General Medicine Lipid Metabolism Mitochondria 0104 chemical sciences Cell biology Cholesterol 030104 developmental biology Gene Expression Regulation Membrane protein Proteolysis Molecular Medicine lipids (amino acids peptides and proteins) Signal transduction Peptide Hydrolases Protein Binding Signal Transduction |
| Zdroj: | ACS Chem Biol |
| ISSN: | 1554-8937 1554-8929 |
| DOI: | 10.1021/acschembio.9b00695 |
| Popis: | Synthesis and regulation of lipid levels and identities is critical for a wide variety of cellular functions, including structural and morphological properties of organelles, energy storage, signaling, and stability and function of membrane proteins. Proteolytic cleavage events regulate and/or influence some of these lipid metabolic processes and as a result help modulate their pleiotropic cellular functions. Proteins involved in lipid regulation are proteolytically cleaved for the purpose of their relocalization, processing, turnover, and quality control, among others. The scope of this review includes proteolytic events governing cellular lipid dynamics. After an initial discussion of the classic example of sterol regulatory element-binding proteins, our focus will shift to the mitochondrion, where a range of proteolytic events are critical for normal mitochondrial phospholipid metabolism and enforcing quality control therein. Recently, mitochondrial phospholipid metabolic pathways have been implicated as important for the proliferative capacity of cancers. Thus, the assorted proteases that regulate, monitor, or influence the activity of proteins that are important for phospholipid metabolism represent attractive targets to be manipulated for research purposes and clinical applications. |
| Databáze: | OpenAIRE |
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