Fasting Serum Taurine-Conjugated Bile Acids Are Elevated in Type 2 Diabetes and Do Not Change With Intensification of Insulin
| Autor: | Marlene Wewalka, Sander M. Houten, Allison B. Goldfine, Corinne Barbato, Mary-Elizabeth Patti |
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| Přispěvatelé: | Paediatric Metabolic Diseases, Laboratory Genetic Metabolic Diseases |
| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
Adult
Blood Glucose Male medicine.medical_specialty Taurine endocrine system diseases Endocrinology Diabetes and Metabolism medicine.medical_treatment Clinical Biochemistry Population Context (language use) Type 2 diabetes Biochemistry Bile Acids and Salts Cohort Studies chemistry.chemical_compound Endocrinology Internal medicine Diabetes mellitus Glucose Intolerance medicine Humans Insulin Endocrine Research education education.field_of_study Dose-Response Relationship Drug business.industry Biochemistry (medical) Type 2 Diabetes Mellitus nutritional and metabolic diseases Fasting Middle Aged medicine.disease Cross-Sectional Studies Diabetes Mellitus Type 2 chemistry Cohort Female business |
| Zdroj: | Journal of clinical endocrinology and metabolism, 99(4), 1442-1451. The Endocrine Society |
| ISSN: | 0021-972X |
| Popis: | Context: Bile acids (BAs) are newly recognized signaling molecules in glucose and energy homeostasis. Differences in BA profiles with type 2 diabetes mellitus (T2D) remain incompletely understood. Objective: The objective of the study was to assess serum BA composition in impaired glucose-tolerant, T2D, and normal glucose-tolerant persons and to monitor the effects of improving glycemia on serum BA composition in T2D patients. Design and Setting: This was a cross-sectional cohort study in a general population (cohort 1) and nonrandomized intervention (cohort 2). Patients and Interventions: Ninety-nine volunteers underwent oral glucose tolerance testing, and 12 persons with T2D and hyperglycemia underwent 8 weeks of intensification of treatment. Main Outcome Measures: Serum free BA and respective taurine and glycine conjugates were measured by HPLC tandem mass spectrometry. Results: Oral glucose tolerance testing identified 62 normal-, 25 impaired glucose-tolerant, and 12 T2D persons. Concentrations of total taurine-conjugated BA were higher in T2D and intermediate in impaired-compared with normal glucose-tolerant persons (P = .009). Univariate regression revealed a positive association between total taurine-BA and fasting glucose (R = 0.37, P |
| Databáze: | OpenAIRE |
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